101001-09-6

Basic information

• Product Name: (3Z)-3-[(4-chlorophenyl)methylidene]-2,3-dihydro-4H-thiochromen-4-one
• CAS NO: 101001-09-6
• Molecular Formula: C₁₆H₁₁ClOS
• Molecular Weight: 286.7759
• Mol File: 101001-09-6.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 463.9°C at 760 mmHg
• Flash Point: 234.3°C
• Density: 1.352g/cm³
• Vapor Pressure: 8.77E-09mmHg at 25°C
• Refractive Index: 1.703
• CAS DataBase Reference: (3Z)-3-[(4-chlorophenyl)methylidene]-2,3-dihydro-4H-thiochromen-4-one(CAS DataBase Reference)
• NIST Chemistry Reference: (3Z)-3-[(4-chlorophenyl)methylidene]-2,3-dihydro-4H-thiochromen-4-one(101001-09-6)
• EPA Substance Registry System: (3Z)-3-[(4-chlorophenyl)methylidene]-2,3-dihydro-4H-thiochromen-4-one(101001-09-6)

Safety Data

• Hazardous Substances Data: 101001-09-6(Hazardous Substances Data)

Usage

Description

(3Z)-3-[(4-chlorophenyl)methylidene]-2,3-dihydro-4H-thiochromen-4-one is a thiochromene derivative with the molecular formula C17H13ClOS. It features a 4H-1-Benzopyran-4-one skeleton with a sulfur atom at the 2-position and a 4-chlorophenyl group attached to the methylidene moiety at the 3-position. Thiochromene derivatives have been studied for their potential pharmacological activities, such as anti-inflammatory, antioxidant, and anticancer properties.

Uses

Used in Pharmaceutical Industry:
(3Z)-3-[(4-chlorophenyl)methylidene]-2,3-dihydro-4H-thiochromen-4-one is used as a potential pharmaceutical candidate for its anti-inflammatory, antioxidant, and anticancer properties. Its unique structure and pharmacological activities make it a promising compound for further research and development in the pharmaceutical industry.
Used in Research and Development:
(3Z)-3-[(4-chlorophenyl)methylidene]-2,3-dihydro-4H-thiochromen-4-one is used as a subject of research for understanding its biological effects and potential applications. Further studies are needed to fully explore its pharmacological activities and to determine its suitability for various therapeutic applications.

Upstream product

• 3528-17-4 2,3-dihydro-4H-[1]benzothiopyran-4-one 
• 104-88-1 4-chlorobenzaldehyde 

Downstream Products

• 866037-94-7 4-(4-chlorophenyl)-5-(2-fluorocarbonyl)phenylthiomethyl-1,3-diphenylpyrazole 
• 866037-90-3 4-(4-chlorophenyl)-1,3-diphenylspiropyrazoline-5,3'-thiochroman-4-one 
• 374551-05-0 (E)-3-(4-chlorobenzylidene)-2,3-dihydro-2-fluorothiochroman-4-one 
• 29309-01-1 3-[1-(4-Chloro-phenyl)-meth-(Z)-ylidene]-1-oxo-1λ⁴-thiochroman-4-one 

Relevant articles and documents

Green chemistry preparation of MgO nanopowders: efficient catalyst for the synthesis of thiochromeno[4,3-b]pyran and thiopyrano[4,3-b]pyran derivatives

A mild and efficient method for the synthesis of thiochro meno[4,3-b]pyran and thiopyrano[4,3-b]pyran derivatives using MgO nanopowders as a catalyst is described. The MgO nanopowders were prepared via a green biosynthesis method using an extract of Rosma

Synthesis of novel tricyclic heterocyclic compounds as potential anticancer agents using chromanone and thiochromanone as synthons

The arylmethylene of benzopyrane or benzothiopyrane 3,4 have been synthesized and condensed with hydrazine, guanidine and thiourea to yield pyrazole 5-8, aminopyrimidine 9,10 and thioxopyrimidine derivatives 11,12, respectively. Compounds 3 or 4 on treatment with malononitrile in the presence of ammonium acetate/acetic acid or in the presence of piperidine/ methanol to yield benzopyrano- and benzothiopyranopyridine 13,14 and benzopyrano- and benzothiopyrane 15,16, respectively. The oxirane of compound 3 is prepared and condensed with CS2 to yield the tricyclic system, thioxothienobenzopyrane 21. Ylidenemalononitrile for the ketone 1 and 2 are synthesized and condensed with aromatic aldehyde in presence of ammonium acetate/acetic acid to yield benzopyranopyridine and benzothiopyranopyridine derivatives 24,25, respectively, which are the isomer of compounds 13,14. Ylidenemalononitrile on condensation with phenylisothiocyanate yields benzo-pyrano- and benzothiopyranothioxopyridine 28,29, respectively.

A New Synthesis of Benzothiopyrano-pyridines and -pyrans.

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