101004-95-9

Basic information

• Product Name: (1-OXO-1,3-DIHYDRO-2H-ISOINDOL-2-YL)(PHENYL)ACETIC ACID
• Synonyms: (1-OXO-1,3-DIHYDRO-2H-ISOINDOL-2-YL)(PHENYL)ACETIC ACID;2-(1-OXO-1,3-DIHYDRO-2H-ISOINDOL-2-YL)-2-PHENYLACETIC ACID;1,3-DIHYDRO-1-OXO-ALPHA-PHENYL-2H-ISOINDOLE-2-ACETIC ACID;2-(1-Oxoisoindolin-2-yl)-2-phenylacetic acid
• CAS NO: 101004-95-9
• Molecular Formula: C₁₆H₁₃NO₃
• Molecular Weight: 267.28
• Mol File: 101004-95-9.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 500.3°Cat760mmHg
• Flash Point: 256.4°C
• Appearance: /
• Density: 1.361g/cm³
• Vapor Pressure: 7.89E-11mmHg at 25°C
• Refractive Index: 1.664
• PKA: 3.11±0.10(Predicted)
• CAS DataBase Reference: (1-OXO-1,3-DIHYDRO-2H-ISOINDOL-2-YL)(PHENYL)ACETIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: (1-OXO-1,3-DIHYDRO-2H-ISOINDOL-2-YL)(PHENYL)ACETIC ACID(101004-95-9)
• EPA Substance Registry System: (1-OXO-1,3-DIHYDRO-2H-ISOINDOL-2-YL)(PHENYL)ACETIC ACID(101004-95-9)

Safety Data

• Hazardous Substances Data: 101004-95-9(Hazardous Substances Data)

Usage

General Description

(1-oxo-1,3-dihydro-2H-isoindol-2-yl)(phenyl)acetic acid is a chemical compound with the molecular formula C17H15NO3. It is a white to off-white powder with a molecular weight of 281.3 g/mol. (1-OXO-1,3-DIHYDRO-2H-ISOINDOL-2-YL)(PHENYL)ACETIC ACID is used as a building block in organic synthesis and in the production of pharmaceuticals and agrochemicals. It has the potential to act as an inhibitor of the enzymes involved in certain biological processes, making it a valuable tool in biochemical and pharmacological research. Additionally, it has been found to exhibit anti-inflammatory and analgesic properties, making it a promising candidate for the development of new therapeutic agents.

InChI:InChI=1/C16H13NO3/c18-15-13-9-5-4-8-12(13)10-17(15)14(16(19)20)11-6-2-1-3-7-11/h1-9,14H,10H2,(H,19,20)

Upstream product

• 2835-06-5 phenylglycin 
• 643-79-8 o-phthalic dicarboxaldehyde 
• 15028-40-7 DL-2-phenylglycine methyl ester hydrochloride 
• 2417-73-4 methyl 2-bromomethylbenzoate 
• 96017-07-1 methyl-2-(1-oxoisoindolin-2-yl)-2-phenylacetate 

Downstream Products

• 96017-13-9 Dimethyl 3-Phenyl-5H-pyrrolo<2,1-a>isoindole-1,2-dicarboxylate 
• 30762-83-5 α-(1-oxoisoindolin-2-yl)phenylacetamide 

Relevant articles and documents

Discovery of Potent and Noncovalent Reversible EGFR Kinase Inhibitors of EGFRL858R/T790M/C797S

In this paper, we describe the discovery and optimization of a series of noncovalent reversible epidermal growth factor receptor inhibitors of EGFRL858R/T790M/C797S. One of the most promising compounds, 25g, inhibited the enzymatic activity of EGFRL858R/T790M/C797S with an IC50 value of 2.2 nM. Cell proliferation assays showed that 25g effectively and selectively inhibited the growth of EGFRL858R/T790M/C797S-dependent cells. This series of compounds, which occupy both the ATP binding site and the allosteric site of the EGFR kinase, may serve as a basis for the development of fourth-generation EGFR inhibitors for L858R/T790M/C797S mutants.

Synthesis of the 5H-Pyrroloisoindole Ring with 1,3-Dipolar Cycloaddition Reactions

The 1,3-dipolar cycloaddition reaction between mesoionic oxazolines, formed from either 1,3-dihydro-2-substituted-2H-isoindole-1-carboxylic acids or 1,3-dihydro-1-oxo-α-substituted-2H-isoindole-2-acetic acids, and dimethylacetylene dicarboxylate has led t