101010-74-6

Basic information

• Product Name: 2-(1,3-thiazol-2-yl)acetonitrile
• Synonyms: 2-(1,3-thiazol-2-yl)acetonitrile;OTAVA-BB BB7118560868;THIAZOL-2-YL-ACETONITRILE;2-Thiazoleacetonitrile;2-Cyanomethylthiazole;2-(Thiazol-2-yl)acetonitrile
• CAS NO: 101010-74-6
• Molecular Formula: C₅H₄N₂S
• Molecular Weight: 124.167
• Mol File: 101010-74-6.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 241.2±23.0 °C(Predicted)
• Appearance: /
• Density: 1.262±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 1.65±0.10(Predicted)
• CAS DataBase Reference: 2-(1,3-thiazol-2-yl)acetonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(1,3-thiazol-2-yl)acetonitrile(101010-74-6)
• EPA Substance Registry System: 2-(1,3-thiazol-2-yl)acetonitrile(101010-74-6)

Safety Data

• Hazardous Substances Data: 101010-74-6(Hazardous Substances Data)

Usage

General Description

2-(1,3-thiazol-2-yl)acetonitrile is a chemical compound with the molecular formula C5H4N2S. It is a white to light yellow solid that is used in the synthesis of various pharmaceuticals and agrochemicals. 2-(1,3-thiazol-2-yl)acetonitrile is also used as an intermediate in the production of other chemicals, such as dyes and in the manufacturing of polymers. It is important to handle 2-(1,3-thiazol-2-yl)acetonitrile with care, as it is considered a hazardous material and may cause skin and eye irritation. Additionally, it may be harmful if ingested or inhaled, and should be stored and handled in accordance with proper safety measures.

Upstream product

• 3034-53-5 2-bromo-1,3-thiazole 
• 1116-98-9 cyanoacetic acid tert-butyl ester 
• 3364-78-1 2-chloromethyl-thiazole 
• 7677-24-9 trimethylsilyl cyanide 
• 3034-52-4 2-chlorothiazole 
• 75-05-8 acetonitrile 

Downstream Products

• 188937-16-8 2-(1,3-thiazol-2-yl)acetic acid 
• 1413914-16-5 3-(4-(7-pivaloyl-5-((2-(trimethylsilyl)ethoxy)methyl)-5H-pyrrolo[2,3-b]pyrazin-2-ylamino)phenyl)-2-(thiazol-2-yl)acrylonitrile 

Relevant articles and documents

Aryl imidazole derivative and application thereof

The invention relates to an aryl imidazole derivative and application thereof. The aryl imidazole derivative is a compound shown as a formula (I) in the description or pharmaceutically acceptable salt thereof. The invention also discloses application of the aryl imidazole derivative in preparation of drugs for treating cancers. The invention further discloses application of the aryl imidazole derivative in preparation of drugs for treating diseases caused by EGFR mutation.

INHIBITORS OF INFLUENZA VIRUS REPLICATION AND USES THEREOF

The invention provides a class of compounds as inhibitors of influenza virus replication, preparation methods thereof, pharmaceutical compositions containing these compounds, and uses of these compounds and pharmaceutical compositions thereof in the treatment of influenza.

HETEROCYCLIC COMPOUNDS FOR THE INHIBITION OF PASK

Disclosed herein are new heterocyclic compounds and compositions and their application as pharmaceuticals for the treatment of disease. Methods of inhibiting PAS Kinase (PASK) activity in a human or animal subject are also provided for the treatment of diseases such as diabetes mellitus.