101030-72-2

Basic information

• Product Name: N-(4-hydroxyphenyl)-3-methylbut-2-enamide
• CAS NO: 101030-72-2
• Molecular Formula: C₁₁H₁₃NO₂
• Molecular Weight: 191.2264
• Mol File: 101030-72-2.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 400.7°C at 760 mmHg
• Flash Point: 196.2°C
• Density: 1.166g/cm³
• Vapor Pressure: 5.38E-07mmHg at 25°C
• Refractive Index: 1.601
• CAS DataBase Reference: N-(4-hydroxyphenyl)-3-methylbut-2-enamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(4-hydroxyphenyl)-3-methylbut-2-enamide(101030-72-2)
• EPA Substance Registry System: N-(4-hydroxyphenyl)-3-methylbut-2-enamide(101030-72-2)

Safety Data

• Hazardous Substances Data: 101030-72-2(Hazardous Substances Data)

Upstream product

• 541-47-9 3-Methylbutenoic acid 
• 104-94-9 4-methoxy-aniline 
• 109729-85-3 N-(4-methoxyphenyl)-3-methyl-2-butenamide 
• 123-30-8 4-amino-phenol 
• 3350-78-5 3,3-Dimethylacryloyl chloride 

Relevant articles and documents

A COMPOUND AS A THYROID HORMONE BETA RECEPTOR AGONIST AND USE THEREOF

Provided herein is a compound as a thyroid hormone β receptor agonist and use thereof. It further relates to a pharmaceutical composition comprising the compound. The compound or the pharmaceutical composition can be used in the manufacture of a medicament for preventing, treating or alleviating diseases regulated by thyroid hormone β receptors, especially in the manufacture of a medicament for treating non-alcoholic fatty liver disease.

INHIBITORS OF DIHYDROCERAMIDE DESATURASE FOR TREATING DISEASE

Disclosed herein are dihydroceramide desaturase 1 (Des1) inhibitor compounds and compositions, which are useful in the treatment of diseases, such as metabolic, cardiovascular, fibrotic, autoimmune/chronic inflammatory diseases, cystic fibrosis, various cancers, neurodegenerative diseases, lipid storage disorders, and ischemia/reperfusion injury, where inhibition of Des1 is expected to be therapeutic to a patient. Methods of inhibition of Des1 activity in a human or animal subject are also provided.

Aluminium chloride-catalyzed intermolecular vs intramolecular friedel-crafts reaction of acrylanilides and 3-chloropropanamides

3-Phenylpropionanilide (4a) is obtained in a yield of 89% from acrylanilide by the treatment with AlCl3/ benzene, compared with a yield of 39% by the 1,4-conjugate addition of phenyllithium. The formation of 4a indicated that an intermolecular Friedel-Crafts reaction occurred, rather than the relatively more facile intramolecular ring cyclization, and provided a more efficient route than a conjugate addition of phenyllithium for the preparation of 3-phenylpropionanilide and its derivatives. Although the methoxy group is an activator of the nucleophilic substitution, introduction of a methoxy substituent at N-phenyl did not increase the competitive capability of the intramolecular cyclization because of AlCl3-catalyzed demethylation to form the ArOAlCl2 complex which decreased the availability of the π-electron in the N-phenyl aromatic system.