Welcome to LookChem.com Sign In|Join Free

CAS

  • or

101039-96-7

Post Buying Request

101039-96-7 Suppliers

Recommended suppliersmore

  • Product
  • FOB Price
  • Min.Order
  • Supply Ability
  • Supplier
  • Contact Supplier

101039-96-7 Usage

General Description

1-(3-azido-2,3-dideoxy-beta-D-threo-pentofuranosyl)pyrimidine-2,4(1H,3H)-dione is a chemical compound that is commonly used in the field of pharmaceuticals and biochemistry. It is a derivative of pyrimidine and is known for its antiviral properties. It has been studied for its potential use in the treatment of HIV and other viral infections. The compound is a nucleoside analog, meaning it mimics the structure of nucleosides found in DNA and RNA. This makes it effective in interfering with viral replication and growth. Additionally, its azido group gives it the ability to bind to the viral reverse transcriptase enzyme, further inhibiting the replication of the virus. Overall, 1-(3-azido-2,3-dideoxy-beta-D-threo-pentofuranosyl)pyrimidine-2,4(1H,3H)-dione shows promise as a potential antiviral agent and is an important subject of ongoing research.

Check Digit Verification of cas no

The CAS Registry Mumber 101039-96-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,1,0,3 and 9 respectively; the second part has 2 digits, 9 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 101039-96:
(8*1)+(7*0)+(6*1)+(5*0)+(4*3)+(3*9)+(2*9)+(1*6)=77
77 % 10 = 7
So 101039-96-7 is a valid CAS Registry Number.

101039-96-7SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 13, 2017

Revision Date: Aug 13, 2017

1.Identification

1.1 GHS Product identifier

Product name 1-[(2R,4R,5S)-4-azido-5-(hydroxymethyl)oxolan-2-yl]pyrimidine-2,4-dione

1.2 Other means of identification

Product number -
Other names HMS2234N04

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:101039-96-7 SDS

101039-96-7Downstream Products

101039-96-7Relevant articles and documents

Lipophilic Triphosphate Prodrugs of Various Nucleoside Analogues

Jia, Xiao,Schols, Dominique,Meier, Chris

, p. 6991 - 7007 (2020)

The antiviral efficacy of many nucleoside analogues is strongly dependent on their intracellular activation by host cellular kinases to yield ultimately the bioactive nucleoside analogue triphosphates (NTP). The metabolic conversion of nucleoside analogues into their triphosphates often proceeds insufficiently. We developed a nucleoside triphosphate (NTP) delivery system (the TriPPPro approach), in which the γ-phosphate is covalently modified by two different biodegradable masking units, one is the acyloxybenzyl (AB) moiety and the other is the alkoxycarbonyloxybenzyl (ACB) group. Such compounds formed NTPs with high selectivity by an enzyme-triggered mechanism in human T-lymphocyte CEM cell extracts loosing first the AB moiety, followed by the ACB group. This enables the bypass of all steps of the intracellular phosphorylation. This approach was applied here to convert some modestly active or even inactive nucleoside analogues into powerful biologically active metabolites. Potent antiviral activity profiles were obtained depending on the lipophilicity of the TriPPPro-NTP prodrugs against HIV-1 and HIV-2 replication in cultures of infected wild-type CD4+ CEM T-cells and more importantly in thymidine kinase-deficient CD4+ T-cells (CEM/TK-). This TriPPPro strategy offers high potential for future antiviral and antitumoral chemotherapies.

Post a RFQ

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

1

What can I do for you?
Get Best Price

Get Best Price for 101039-96-7