101040-16-8Relevant academic research and scientific papers
Stereospecific transformation of protected Pa-H group into Pa-O or Pa-N group in one-pot reaction
Yao, Qiuli,Yuan, Chengye
, p. 10985 - 10990 (2013/03/13)
A general and efficient procedure for converting 1,1- diethoxyalkylphosphinates into phosphonates or phosphonamides is described by the application of bromine with moderate to high yields and good purity in a one-pot reaction. H-Phosphinate reacts stereospecifically with bromine and subsequently couples with nucleophile to form the corresponding optically active R1P(O)(OEt)X with retention of configuration at the phosphorus center. For α-amino-H-phosphinates, the transformation could be realized without the protection of the amino group.
An efficient synthesis of diethyl 1-aminoalkylphosphonate hydrochlorides via the intermediate diethyl 1-azidoalkylphosphonates
Gajda,Matusiak
, p. 2193 - 2203 (2007/10/02)
The title compounds 4 have been obtained in high yields in a one-step sequence by the Mitsunobu reaction of diethyl 1-hydroxyalkylphosphonates 1 with hydrazoic acid, and subsequence treatment of the intermediate azides 2 with triphenylphosphine, followed
