101043-65-6 Usage
Chemical Category
Nitroso compounds
Known health hazards
Potential health risks
Sub-category
Nitrosated polycyclic aromatic hydrocarbons
Common presence
Environmental pollutants such as diesel exhaust and cigarette smoke
Formation
Through the nitration and nitrosation of pyrene
Pyrene
A common component of fossil fuel combustion emissions
Potential health effects
Identified as a potential carcinogen, contributes to the development of cancer in humans
Environmental and health concerns
Highlights the need for further research and regulation to minimize exposure to this hazardous chemical.
Check Digit Verification of cas no
The CAS Registry Mumber 101043-65-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,1,0,4 and 3 respectively; the second part has 2 digits, 6 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 101043-65:
(8*1)+(7*0)+(6*1)+(5*0)+(4*4)+(3*3)+(2*6)+(1*5)=56
56 % 10 = 6
So 101043-65-6 is a valid CAS Registry Number.
InChI:InChI=1/C16H8N2O3/c19-17-13-7-3-9-2-6-12-14(18(20)21)8-4-10-1-5-11(13)15(9)16(10)12/h1-8H
101043-65-6Relevant articles and documents
Synthesis of oligonucleotides containing 2′-deoxyguanosine adducts of nitropyrenes
Colis, Laureen C.,Chakraborti, Debasis,Hilario, Pablo,McCarty, Christopher,Basu, Ashis K.
body text, p. 67 - 77 (2009/05/30)
Two different approaches to synthesize oligonucleotides containing the 2′-deoxyguanosine adducts formed by nitropyrenes are described. A direct reaction of an unmodified oligonucleotide with an activated nitropyrene derivative is a convenient biomimetic approach for generating the major adducts in DNA. A total synthetic approach, by contrast, involves several synthetic steps, including Buchwald-Hartwig Pd-catalyzed coupling, but can be used for incorporating both the major and minor adducts in DNA in high yield. Copyright Taylor & Francis Group, LLC.
