101078-48-2

Basic information

• Product Name: N-(4-chlorophenyl)-4-methylbenzenecarbothioamide
• Synonyms: benzenecarbothioamide, N-(4-chlorophenyl)-4-methyl-; N-(4-Chlorophenyl)-4-methylbenzenecarbothioamide
• CAS NO: 101078-48-2
• Molecular Formula: C₁₄H₁₂ClNS
• Molecular Weight: 261.7698
• Mol File: 101078-48-2.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 369.9°C at 760 mmHg
• Flash Point: 177.5°C
• Density: 1.28g/cm³
• Vapor Pressure: 1.15E-05mmHg at 25°C
• Refractive Index: 1.686
• CAS DataBase Reference: N-(4-chlorophenyl)-4-methylbenzenecarbothioamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(4-chlorophenyl)-4-methylbenzenecarbothioamide(101078-48-2)
• EPA Substance Registry System: N-(4-chlorophenyl)-4-methylbenzenecarbothioamide(101078-48-2)

Safety Data

• Hazardous Substances Data: 101078-48-2(Hazardous Substances Data)

Upstream product

• 2617-79-0 N-(4-chlorophenyl)formamide 
• 104-87-0 4-methyl-benzaldehyde 
• 622-97-9 1-ethenyl-4-methylbenzene 
• 106-47-8 4-chloro-aniline 
• 99-94-5 p-Toluic acid 
• 874-60-2 4-methyl-benzoyl chloride 
• 33667-89-9 N-(4-chlorophenyl)-4-methylbenzamide 

Downstream Products

• 101078-59-5 6-chloro-2-(p-tolyl)benzo[d]thiazole 
• 101078-68-6 Acetic acid 2-[4-(diethoxy-phosphorylmethyl)-phenyl]-benzothiazol-7-yl ester 
• 101078-71-1 [4-(7-Hydroxy-benzothiazol-2-yl)-benzyl]-phosphonic acid diethyl ester 
• 101078-58-4 Acetic acid 2-p-tolyl-benzothiazol-7-yl ester 
• 101078-55-1 2-p-Tolyl-benzothiazol-7-ol 
• 101078-52-8 2-(4-methylphenyl)-7-methoxybenzothiazole 

Relevant articles and documents

Mixed bases mediated synthesis of thioamides in water

A mixed bases mediated protocol is developed to synthesize thioamides from N-aryl or N-alkylamide, aldehyde and elemental sulfur in water. This reaction requires no addition of external oxidant and avoids large excess of amides. Various functional groups

Base-Controlled Three Component Reactions of Amines, Elemental Sulfur, and Styrenes: Synthesis of Thioamides under Metal-Free Conditions

Three component reactions of olefins, amines, and sulfur were studied. Thioamidation of styrenes is base-controlled, and 2-phenylethanethioamides and benzothioamides were obtained selectively in the presence of two different bases. This protocol offers a simple and efficient procedure for the synthesis of thioamides.

ANTIMYCOBACTERIAL THIOBENZANILIDES

A group of 30 thiobenzanilides active against Mycobacterium kansasii have been synthesized and their 1H NMR and UV spectra and RM values (TLC on silica gel impregnated with methylsilicone oil) have been measured.From the correlation between the chemical shifts of the thioamide proton in the 1H NMR spectra and the Hammett constants it can be concluded that the substituents in both aromatic rings uniformly affect the electron density of the thioamide group.The antimycobacterial activity is probably connected with local molecular parameters and can be considered to be approximately additive with respect to both parts of the molecule.