101078-75-5

Usage

Uses

Used in Biomedical Research:
6-methoxy-2-p-tolylbenzo[d]thiazole is used as a cell viability marker for assessing the effects of substances on cellular metabolism and viability. It is taken up by living cells and converted into a purple formazan product by mitochondrial dehydrogenases, providing a quantitative measure of cell viability.
Used in MTT Assay:
In the MTT assay, 6-methoxy-2-p-tolylbenzo[d]thiazole is used as a colorimetric indicator for cell viability. The assay is widely employed in research to evaluate the cytotoxicity of various compounds, drugs, and environmental factors on cells, as well as to study the effects of treatments on cell proliferation and survival.
Used in Drug Development:
6-methoxy-2-p-tolylbenzo[d]thiazole plays a crucial role in drug development by helping researchers assess the safety and efficacy of new compounds. By measuring cell viability in response to drug candidates, researchers can determine the potential cytotoxic effects and select the most promising compounds for further development.
Used in Environmental Toxicity Studies:
In environmental research, 6-methoxy-2-p-tolylbenzo[d]thiazole is used to evaluate the toxicity of pollutants, chemicals, and other environmental factors on cells. This helps in understanding the impact of these factors on human health and the environment, and in developing strategies to mitigate their harmful effects.
Used in Cancer Research:
6-methoxy-2-p-tolylbenzo[d]thiazole is also employed in cancer research to study the effects of anticancer drugs and other treatments on cancer cells. By measuring cell viability in response to these treatments, researchers can evaluate their potential therapeutic effects and select the most effective approaches for cancer treatment.

Upstream product

• 6232-88-8 4-bromomethylbenzoic Acid 
• 6274-29-9 2-amino-5-methoxy-thiophenol 
• 1747-60-0 6-methoxybenzothiazol-2-ylamine 

Downstream Products

• 101078-61-9 diethyl {[4-(6-methoxybenzothiazol-2-yl)phenyl]methyl}phosphonate 
• 1018070-82-0 (E)-2-(4-(4-(methylamino)styryl)phenyl)benzo[d]thiazol-6-ol 

Relevant academic research and scientific papers

Compounds with high selectivity to tau aggregates, tau-targeting probe comprising the same, and preparation method thereof

The present invention relates to: a compound represented by chemical formula 1, which exhibits excellent binding force to tau aggregates, thereby being useful for early diagnosis of degenerative brain diseases including dementia, and for preventing and treating the same; a method for manufacturing the same; and a pharmaceutical composition comprising the same. The compound according to the present invention exhibits a high selectivity to tau aggregates compared to beta amyloid, and thus the compound can be usefully used for the early diagnosis and prevention or treatment of diseases related to tau aggregates including dementia.COPYRIGHT KIPO 2019

Compounds with high selectivity to tau aggregates, tau-targeting probe comprising the same, and preparation method thereof

The present invention relates to: a compound represented by chemical formula 1, which exhibits excellent binding force to tau aggregates, thereby being useful for early diagnosis of degenerative brain diseases including dementia, and for preventing and treating the same; a method for manufacturing the same; and a pharmaceutical composition comprising the same. The compound according to the present invention exhibits a high selectivity to tau aggregates compared to beta amyloid, thereby being able to be usefully used for early diagnosis, prevention or treatment of diseases related to tau aggregates including dementia.COPYRIGHT KIPO 2020

The flocculated acryloyldimethyltauric molecule ligand

Provided are certain benzothiazole, imidazothiazole, imidazopyrimidine and imidazopyridine compounds, including, for example: formula (I) and pharmaceutically and physiologically acceptable salts, hydrates, and solvates thereof. Such compounds can be used as diagnostic ligands or labels of tau protein and PHF.

Organic Phosphorus Compounds. 1. 4-(Benzothiazol-2-yl)benzylphosphonate as Potent Calcium Antagonistic Vasodilator

A series of 4-(benzothiazol-2-yl)benzylphosphonic acid dialkyl ester were synthesized and evaluated for coronary vasodilatory activity by Langendorff's method in the isolated guinea pig heart. Many of the phosphonic acid dialkyl esters exhibited vasodilat