101079-62-3

Usage

Uses

Used in Pharmaceutical Industry:
6-Chloro-3-Methylpyrimidin-4(3H)-one is used as a key intermediate in the synthesis of various pharmaceuticals. Its unique structure allows for the development of new drugs with specific therapeutic properties, contributing to the advancement of medicine and healthcare.
Used in Agrochemical Industry:
In the agrochemical sector, 6-Chloro-3-Methylpyrimidin-4(3H)-one serves as a building block for the creation of novel agrochemicals. Its incorporation into these products can enhance crop protection and yield, supporting sustainable agriculture and food security.
Used in Research and Development:
6-Chloro-3-Methylpyrimidin-4(3H)-one is utilized as a research chemical in biochemical and medical studies. Its unique properties make it a valuable tool for understanding biological processes and developing new therapeutic approaches.
Used in Organic Chemistry:
6-Chloro-3-Methylpyrimidin-4(3H)-one has potential applications in the field of organic chemistry, where it can be used to develop new materials and compounds with diverse functionalities. Its versatility and reactivity contribute to the discovery of innovative solutions in various industries.

Upstream product

• 4765-77-9 6-Chloro-3,4-dihydro-4-oxopyrimidine 
• 74-88-4 methyl iodide 

Downstream Products

• 1458655-44-1 6-(4-iodo-3,5-dimethylphenyl)-3-methylpyrimidin-4(3H)-one 
• 1458655-42-9 6-(4-amino-3,5-dimethylphenyl)-3-methylpyrimidin-4(3H)-one 

Relevant academic research and scientific papers

Design, synthesis, and antifungal activities of new β-methoxyacrylate analogues

Strobilurins have become one of the most important classes of agricultural fungicides. To search for new strobilurin derivatives with high activity against resistant pathogens, a series of new β-methoxyacrylate analogues containing substituted pyrimidine in the side chain with strobilurin pharmacophore were synthesized and their biological activities were tested. The compounds were confirmed and characterized by 1H-NMR, elemental analysis and mass spectroscopy. The bioassays indicated that most of the compounds 1 exhibited potent antifungal activities against Colletotrichum orbiculare, Botrytis cinerea Pers and Phytophthora capsici Leonian at a concentration of 50 μg mL-1. Notably, compound 1b (R = 2,5-dimethylphenyl) showed better antifungal activity against all the tested fungi than the commercial strobilurin fungicide azoxystrobin.

METHODS AND COMPOSITIONS FOR MODULATING SPLICING

Described herein are small molecule splicing modulator compounds that modulate splicing of mRNA, such as pre-mRNA, encoded by genes, and methods of use of the small molecule splicing modulator compounds for modulating splicing and treating diseases and conditions.

NEW INDANYLOXYDIHYDROBENZOFURANYLACETIC ACIDS

The present invention relates to compounds of general formula I, wherein the groups R1, R2 and m are defined as in claim 1, which have valuable pharmacological properties, in particular bind to the GPR40 receptor and modulate its activity. The compounds are suitable for treatment and prevention of diseases which can be influenced by this receptor, such as metabolic diseases, in particular diabetes type 2.

NEW INDANYLOXYDIHYDROBENZOFURANYLACETIC ACID DERIVATIVES AND THEIR USE AS GPR40 RECEPTOR AGONISTS

The present invention relates to compounds of general formula I, (I), wherein the groups R1, R2 and m are defined as in claim 1, which have valuable pharmacological properties, in particular bind to the GPR40 receptor and modulate its activity. The compounds are suitable for treatment and prevention of diseases which can be influenced by this receptor, such as metabolic diseases, in particular diabetes type 2.