101080-64-2

Upstream product

• 85053-06-1 2-(3,4-dichlorophenylsulfanyl)-1-ethanol 
• 67141-36-0 sodium 3,4-dichlorobenzenethiolate 
• 5858-17-3 3,4-dichlorothiophenol 

Downstream Products

• 25062-92-4 2-pentachlorobenzenesulfonyl-ethanol 
• 548740-03-0 2-(3,4-dichlorophenylsulfonyl)ethyl (E)-3-phenyl-2-propenoate 
• 548740-02-9 2-(3,4-dichlorophenylsulfonyl)ethyl 3-phenylpropanoate 
• 5535-46-6 3,4-dichlorophenyl vinyl sulfone 

Relevant academic research and scientific papers

π-deficient 2-(arylsulfonyl)ethyl esters as protecting groups for carboxylic acids

Several π-deficient 2-(arylsulfonyl)ethyl groups have been studied as carboxylic acid protecting groups. The 2-[3,5-bis(trifluoromethyl)phenylsulfonyl]ethyl group is the most easily removed protecting group for acids under mild basic conditions using aqueous NaHCO3.

Process for producing [2-(arylsulfonyl) ethenyl] benzene derivatives

The present invention provides a safer and more efficient process for producing [2-(arylsulfonyl)ethenyl]benzene derivatives of the formula (3): wherein R1, R2, R3 and R4 are the same or different and each independently represent a hydrogen, fluorine, or chlorine atom, a lower alkyl group, or the like, and two adjacent R3 and R4 may bond each other at their terminals to form a ring, which the process is characterized in that a 2-(arylsulfonyl)ethanol of formula (1): wherein R1 and R2 are as defined above, and an acid anhydride are reacted in the presence of a base, and the reaction liquid obtained is supplied to a reaction with an aromatic halide of formula (2): wherein X represents a chlorine, bromine, or iodine atom, and R3 and R4 are the same as defined above, in the presence of a palladium catalyst and a base.