1010800-73-3

Basic information

• Product Name: 3-(3-methoxyphenyl)-4,4-dimethyl-1H-pyrazol-5(4H)-one
• Synonyms: 3-(3-methoxyphenyl)-4,4-dimethyl-1H-pyrazol-5(4H)-one
• CAS NO: 1010800-73-3
• Molecular Weight: 218.255
• Mol File: 1010800-73-3.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 3-(3-methoxyphenyl)-4,4-dimethyl-1H-pyrazol-5(4H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(3-methoxyphenyl)-4,4-dimethyl-1H-pyrazol-5(4H)-one(1010800-73-3)
• EPA Substance Registry System: 3-(3-methoxyphenyl)-4,4-dimethyl-1H-pyrazol-5(4H)-one(1010800-73-3)

Safety Data

• Hazardous Substances Data: 1010800-73-3(Hazardous Substances Data)

Upstream product

• 1711-05-3 m-anisoyl chloride 
• 343305-12-4 methyl 3-(3-methoxyphenyl)-2-methyl-3-oxopropanoate 
• 37951-49-8 1-(3-methoxyphenyl)propan-1-one 
• 586-38-9 3-Methoxybenzoic acid 
• 152121-82-9 N,3‐dimethoxy‐N‐methylbenzamide 

Downstream Products

• 1010800-74-4 3-(3-hydroxyphenyl)-4,4-dimethyl-1H-pyrazol-5(4H)-one 
• 1010801-86-1 C₂₉H₃₁F₃N₆O₄ 

Relevant articles and documents

Identification of Phenylpyrazolone Dimers as a New Class of Anti-Trypanosoma cruzi Agents

Chagas disease is becoming a worldwide problem; it is currently estimated that over six million people are infected. The two drugs in current use, benznidazole and nifurtimox, require long treatment regimens, show limited efficacy in the chronic phase of infection, and are known to cause adverse effects. Phenotypic screening of an in-house library led to the identification of 2,2′-methylenebis(5-(4-bromophenyl)-4,4-dimethyl-2,4-dihydro-3H-pyrazol-3-one), a phenyldihydropyrazolone dimer, which shows an in vitro pIC50 value of 5.4 against Trypanosoma cruzi. Initial optimization was done by varying substituents of the phenyl ring, after which attempts were made to replace the phenyl ring. Finally, the linker between the dimer units was varied, ultimately leading to 2,2′-methylenebis(5-(3-bromo-4-methoxyphenyl)-4,4-dimethyl-2,4-dihydro-3H-pyrazol-3-one (NPD-0228) as the most potent analogue. NPD-0228 has an in vitro pIC50 value of 6.4 against intracellular amastigotes of T. cruzi and no apparent toxicity against the human MRC-5 cell line and murine cardiac cells.

PYRIDAZINONE DERIVATIVE AND PDE INHIBITOR CONTAINING THE SAME AS ACTIVE INGREDIENT

It is to provide a novel pyridazinone derivative represented by the following general formula (1), which is useful as a pharmaceutical and has a phosphodiesterase inhibitory action: wherein R1 represents H or C1-6 alkyl, each of R2 and R3 represents H, X, C1-6 alkoxy, Z represents O or S, and A represents AA or BB, wherein AA represents: and BB represents: wherein R4 represents H or C1-6 alkyl, and each of R5 and R6 represents C1-6 alkyl.