101085-21-6

Basic information

• Product Name: (E)-3-(4-broMophenyl)-2-cyanoacrylaMide
• Synonyms: (E)-3-(4-broMophenyl)-2-cyanoacrylaMide
• CAS NO: 101085-21-6
• Molecular Formula: C₁₀H₇BrN₂O
• Molecular Weight: 251.07938
• Mol File: 101085-21-6.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (E)-3-(4-broMophenyl)-2-cyanoacrylaMide(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-3-(4-broMophenyl)-2-cyanoacrylaMide(101085-21-6)
• EPA Substance Registry System: (E)-3-(4-broMophenyl)-2-cyanoacrylaMide(101085-21-6)

Safety Data

• Hazardous Substances Data: 101085-21-6(Hazardous Substances Data)

Usage

General Description

(E)-3-(4-broMophenyl)-2-cyanoacrylaMide is an organic compound that belongs to the class of cyanoacrylates, which are commonly used as fast-acting adhesives. It is composed of a cyano group, an acrylamide group, and a 4-bromophenyl group. (E)-3-(4-broMophenyl)-2-cyanoacrylaMide is commonly used in the field of organic synthesis as a reagent to form carbon-carbon bonds through a process known as Michael addition. It is also used in the preparation of polymer-based materials and in the production of medical-grade adhesives. Additionally, (E)-3-(4-broMophenyl)-2-cyanoacrylaMide may also have potential applications in the pharmaceutical industry for the synthesis of biologically active molecules.

Upstream product

• 2826-24-6 4-bromobenzylidenemalononitrile 
• 1352994-24-1 5-amino-3-(4-bromophenyl)-2,3-dihydroisoxazole-4-carbonitrile 
• 1122-91-4 4-bromo-benzaldehyde 
• 107-91-5 cyanoacetic acid amide 

Downstream Products

• 254453-33-3 4-(4-bromophenyl)-5-cyano-3-methyl-1-phenyl-7H-pyrazolo[3,4-b]pyridin-6-one 
• 1453857-44-7 3,8-diamino-4,10-di(4-bromophenyl)-4,10-dihydrochromeno[6,5-f]chromene-2,9-dicarbonitrile 
• 496874-61-4 3-amino-9-hydroxy-1-(4-bromophenyl)-1H-benzo[f]chromen-2-carbonitrile 
• 1453857-41-4 2-hydroxy-4-(4-bromophenyl)-6-methyl-5-oxo-5,6-dihydro-4H-pyrano[3,2-c]quinolin-3-carbonitrile 
• 1255086-53-3 2-amino-4-(4-bromophenyl)-1-(4-chlorophenyl)-7,7-dimethyl-1,4,5,6,7,8-hexahydroquinolin-5-one 
• 77530-12-2 C₁₈H₁₃N₅O 
• 77530-20-2 [4-((Z)-2-Carbamoyl-2-cyano-vinyl)-benzyl]-ethyl-diphenyl-phosphonium; bromide 

Relevant articles and documents

Rare-earth (RE) exchanged NaY zeolite promoted Knoevenagel condensation

Knoevenagel condensation is assisted by rare-earth exchanged NaY zeolites wherein various functionalized arylaldehydes react readily with active methylene compounds to produce corresponding olefinic products.

Bismuth (III) Triflate: A Mild, Efficient Promoter for the Synthesis of Trisubstituted Alkenes through Knoevenagel Condensation

In this work, smooth efficient and eco-friendly two component coupling method is reported for the synthesis of Knoevenagel Condensation product in presence of Bi(OTf)3 catalyst under solvent free condition. Catalyst has participated in condensation between substituted aldehydes (aromatic and hetero-aromatic) and active methylene compounds (ethyl cyanoacetate, malononitrile and cyanoacetamide) effectively to generate an excellent yield of the product. Bi(OTf)3 catalyst is stable, inexpensive and easily available was used for four times in this reaction without loss of catalytic activity. [Formula Presented]

Determination of thermodynamic affinities of various polar olefins as hydride, hydrogen atom, and electron acceptors in acetonitrile

A series of 69 polar olefins with various typical structures (X) were synthesized and the thermodynamic affinities (defined in terms of the molar enthalpy changes or the standard redox potentials in this work) of the polar olefins obtaining hydride anions, hydrogen atoms, and electrons, the thermodynamic affinities of the radical anions of the polar olefins (X ?-) obtaining protons and hydrogen atoms, and the thermodynamic affinities of the hydrogen adducts of the polar olefins (XH?) obtaining electrons in acetonitrile were determined using titration calorimetry and electrochemical methods. The pure Ci - 'C π-bond heterolytic and homolytic dissociation energies of the polar olefins (X) in acetonitrile and the pure Ci - 'C π-bond homolytic dissociation energies of the radical anions of the polar olefins (X?-) in acetonitrile were estimated. The remote substituent effects on the six thermodynamic affinities of the polar olefins and their related reaction intermediates were examined using the Hammett linear free-energy relationships; the results show that the Hammett linear free-energy relationships all hold in the six chemical and electrochemical processes. The information disclosed in this work could not only supply a gap of the chemical thermodynamics of olefins as one class of very important organic unsaturated compounds but also strongly promote the fast development of the chemistry and applications of olefins.