1010858-04-4Relevant articles and documents
Optimization of the heterocyclic core of the quinazolinone-derived CXCR3 antagonists
Li, An-Rong,Johnson, Michael G.,Liu, Jiwen,Chen, Xiaoqi,Du, Xiaohui,Mihalic, Jeffrey T.,Deignan, Jeffrey,Gustin, Darin J.,Duquette, Jason,Fu, Zice,Zhu, Liusheng,Marcus, Andrew P.,Bergeron, Phillipe,McGee, Lawrence R.,Danao, Jay,Lemon, Bryan,Carabeo, Teresa,Sullivan, Timothy,Ma, Ji,Tang, Liang,Tonn, George,Collins, Tassie L.,Medina, Julio C.
, p. 688 - 693 (2008/09/18)
A series of six-six and six-five fused heterocyclic CXCR3 antagonists has been synthesized and their activities evaluated in an [125I]-IP-10 displacement assay and an ITAC mediated in vitro cell migration assay. The pharmacokinetic properties o