101097-48-7Relevant articles and documents
Bi(OTf)3-catalyed One-pot Synthesis of α-Halo-β-amino Ketones and Acyl Aziridines from 3-Aryl Propargyl Alcohols
Zhang, Qinglin,Duan, Yongbin,Guo, Huifeng,Yang, Hong,Zhai, Jiulong,Li, Tiantian,Wang, Zhihai,Lu, Xiaolei,Wang, Yan,Yin, Yan
, p. 1832 - 1838 (2021)
A Bi(OTf)3-catalyed reaction of 3-aryl propargyl alcohols with sulfonamide and halogen source was firstly investigated, which provided a facile route for the synthesis of a large variety of α-halo-β-amino ketones. The key intermediates, β-amino
Aziridin-2-yl-(aryl) ketone derivative and preparation method thereof
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Paragraph 0121-0125, (2021/08/06)
The invention discloses an aziridin-2-yl-(aryl) ketone derivative and a preparation method thereof, and according to the preparation method, 3-aryl substituted propargyl alcohol, N-protected amine and N-halogenated succinimide are subjected to a multi-step cascade reaction to realize one-pot synthesis of the aziridin-2-yl-(aryl) ketone derivative. The yield of aziridin-2-yl-(aryl) ketone ranges from 70% to 90%, the method has the advantages of being easy to operate, mild in condition, high in yield and the like, and a brand-new synthesis method is provided for derivatives of aziridin-2-yl-(aryl) ketone.