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1011-47-8

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1011-47-8 Usage

General Description

1-Quinolin-2-ylethanone, also known as 2-Acetylquinoline, is a heterocyclic aromatic organic compound with the formula C11H9NO. It is a derivative of quinoline with an acetyl group attached to its second carbon. Quinoline itself is a nitrogen containing two ring compound found in many natural products, including some alkaloids and antimalarial drugs. The compound is recognized for its various biological activities including antimalarial, antibacterial, anticancer, and anti-inflammatory effects. The chemical structure of 1-quinolin-2-ylethanone includes a benzene ring fused to a pyridine ring, resulting in a complex molecular architecture. In terms of its physical properties, it is typically found as a crystalline solid.

Check Digit Verification of cas no

The CAS Registry Mumber 1011-47-8 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,0,1 and 1 respectively; the second part has 2 digits, 4 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 1011-47:
(6*1)+(5*0)+(4*1)+(3*1)+(2*4)+(1*7)=28
28 % 10 = 8
So 1011-47-8 is a valid CAS Registry Number.
InChI:InChI=1/C11H9NO/c1-8(13)10-7-6-9-4-2-3-5-11(9)12-10/h2-7H,1H3

1011-47-8SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 15, 2017

Revision Date: Aug 15, 2017

1.Identification

1.1 GHS Product identifier

Product name 1-quinolin-2-ylethanone

1.2 Other means of identification

Product number -
Other names 1-Quinolin-2-yl-ethanone

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:1011-47-8 SDS

1011-47-8Relevant articles and documents

Synthesis of Aryl Methyl Ketones mediated by Cobalt Tetracarbonyl Anion

Miura, Masahiro,Akase, Fumiaki,Nomura, Masakatsu

, p. 241 - 242 (1986)

The reaction of aryl halides with excess of methyl iodide in the presence of cobalt tetracarbonyl anion (generated under phase-transfer conditions), gave aryl ketones along with aromatic carboxylic acids.

Chiral ferrocenyl ligands with bidentate pyridine donors. Synthesis and application in Pd-catalyzed asymmetric allylic alkylation of 1,3-diphenylpropenyl-1-esters

Mroczek, Agnieszka,Erre, Giulia,Taras, Rossana,Gladiali, Serafino

, p. 1921 - 1927 (2010)

A synthetic procedure relying on the Friedlaender condensation of enantiopure α-amino ferrocenecarboxaldeyde has been devised for the regio-designed elaboration of a pyridine nucleus fused onto the ferrocene scaffold. Three novel bidentate ligands with different pyridine nitrogen donors featuring the [3,2-b]ferrocenopyridine fragment a as the sole chirogenic element have been prepared in enantiopure form through a multi step route involving the diastereoselective deprotonation of a chiral acetal of ferrocenecarboxaldehyde in the stereodetermining step. The ligands were assessed in the Pd-catalyzed allylic alkylation of 1,3-diphenyl-2-propenyl esters with good stereoselectivity.

2-Quinolinecarboxaldehyde: an unusual partner in the Henry reaction and subsequent elimination

Nomland, Ashley,Hills, Ivory D.

, p. 5511 - 5514 (2008)

2-Quinolinecarboxaldehyde participates in a standard Henry reaction when combined with a nitroalkane and catalytic amounts of base. However, water is not readily eliminated from the resulting β-nitro alcohol intermediate to form the expected nitroalkene. Instead, the elimination of nitrous acid is observed furnishing an unexpected ketone product.

Simple and mild method for preparation of α-pyridinecarboxylates and α-pyridyl ketones via trimethylstannyl derivatives

Yamamoto,Ouchi,Tanaka

, p. 1028 - 1030 (1995)

Alkoxycarbonylation and acylation at the α-position of pyridine, quinoline, and isoquinoline via the respective trimethylstannyl derivatives were satisfactorily performed by employing ethyl chloroglyoxylate and acylformyl chloride under mild conditions.

Design, synthesis, and antibacterial evaluation of PFK-158 derivatives as potent agents against drug-resistant bacteria

Wang, Wei,Zhang, You-Wen,Hu, Shang-Jiu,Niu, Wei-Ping,Zhang, Guo-Ning,Zhu, Mei,Wang, Ming-Hua,Zhang, Fan,Li, Xue-Mei,Wang, Ju-Xian

supporting information, (2021/04/12)

Infections caused by antibiotic resistant bacteria are a major health concern throughout the world. It is well known that PFK-158 can enhance the antibacterial effect of polymyxin, but its own anti-bactericidal effect is rarely discussed. In order to inve

Metal-free C-H methylation and acetylation of heteroarenes with PEG-400

Kudale, Vishal Suresh,Wang, Jeh-Jeng

supporting information, p. 3506 - 3511 (2020/06/25)

The generation of a methyl carbon source from renewable and cheap sources is challenging. Herein, we describe a novel and an efficient route for methylation and acetylation of aza-heteroarenes using PEG-400 under O2and TsOH·H2O for the first time by tuning the reaction conditions using a different set of starting materials. The key features of the current protocol are oxidative C-O and C-C bond scission under metal-free conditions with good functional group tolerance, and a broad substrate scope. The potential applicability of the designed methodology was demonstrated for the synthesis of central nervous system (CNS) depressant and anticonvulsant drug molecules by a one-pot strategy.

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