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1011-51-4

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1011-51-4 Usage

General Description

5-(4-Methoxyphenyl)oxazole, also known as MPO, is a chemical compound identified by the CAS number: 66640-36-0. This organic compound is categorized under the class of oxazoles, which are aromatic compounds comprising an oxazole ring - a five-membered ring structure consisting of two carbon atoms, two nitrogen atoms, and one oxygen atom. The chemical formula for 5-(4-Methoxyphenyl)oxazole is C10H9NO2. The unique property of methoxy group -CH3O attached to the phenyl ring makes it commonly used in pharmaceutical research and organic synthesis due to its ability to enhance drug-lipid membrane permeability, overall adding more attributes in medicinal chemistry. Specific details about its physical properties, safety measures, and toxicity need to be further consulted with the proper material safety data sheet (MSDS).

Check Digit Verification of cas no

The CAS Registry Mumber 1011-51-4 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,0,1 and 1 respectively; the second part has 2 digits, 5 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 1011-51:
(6*1)+(5*0)+(4*1)+(3*1)+(2*5)+(1*1)=24
24 % 10 = 4
So 1011-51-4 is a valid CAS Registry Number.
InChI:InChI=1/C10H9NO2/c1-12-9-4-2-3-8(5-9)10-6-11-7-13-10/h2-7H,1H3

1011-51-4SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 15, 2017

Revision Date: Aug 15, 2017

1.Identification

1.1 GHS Product identifier

Product name 5-(4-methoxyphenyl)-1,3-oxazole

1.2 Other means of identification

Product number -
Other names -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
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More Details:1011-51-4 SDS

1011-51-4Relevant articles and documents

Structure-Activity Relationships of New Natural Product-Based Diaryloxazoles with Selective Activity against Androgen Receptor-Positive Breast Cancer Cells

Robles, Andrew J.,McCowen, Shelby,Cai, Shengxin,Glassman, Michaels,Ruiz, Francisco,Cichewicz, Robert H.,McHardy, Stanton F.,Mooberry, Susan L.

, p. 9275 - 9289 (2017)

Targeted therapies for ER+/PR+ and HER2-amplified breast cancers have improved patient survival, but there are no therapies for triple negative breast cancers (TNBC) that lack expression of estrogen and progesterone receptors (ER/PR), or amplification or

Reaction Conditions for the Regiodivergent Direct Arylations at C2- or C5-Positions of Oxazoles using Phosphine-Free Palladium Catalysts

Shi, Xinzhe,Soulé, Jean-Fran?ois,Doucet, Henri

, p. 4748 - 4760 (2019/09/12)

Two sets of reaction conditions for the regiodivergent C2- or C5- direct arylations of oxazole are reported. In both cases, phosphine-free catalysts and inexpensive bases were employed allowing the access to the arylated oxazoles in moderate to high yields. Using Pd(OAc)2/KOAc as catalyst and base, regioselective C5-arylations were observed; whereas, using Pd(acac)2/Cs2CO3 system, the arylation occurred at the C2-position of oxazole. The higher reactivity of C5-H bond of oxazole as compared to the C2-H bond in the presence of Pd(OAc)2/KOAc system is consistent with a concerted metalation deprotonation mechanism; whereas the C2-arylation likely occurs via a simple base deprotonation of the oxazole C2-position. Then, from these C2- or C5-arylated oxazoles, a second palladium-catalyzed direct C?H bond arylation affords 2,5-diaryloxazoles with two different aryl groups. We also applied these sequential arylations to the straightforward synthesis of 2-arylphenanthro[9,10-d]oxazoles via three C?H bond functionalization steps. The Ru-catalyzed C?H arylation of the aryl unit of 2-aryloxazoles is also described. (Figure presented.).

Improvement of the Van Leusen reaction in the presence of β-cyclodextrin: A green and efficient synthesis of oxazoles in water

Rahimzadeh, Golnaz,Kianmehr, Ebrahim,Mahdavi, Mohammad

, p. 923 - 926 (2017/12/18)

An efficient approach for the synthesis of oxazoles through the Van Leusen reaction in the presence of β-cyclodextrin is described. In aqueous medium using β-cyclodextrin as a supramolecular catalyst, tosylmethyl isocyanide was deprotonated by triethylami

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