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1011460-56-2

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1011460-56-2 Usage

General Description

N-METHOXYMETHYL-1-TRIFLUOROMETHYL-CYCLOPROPANECARBOXYLIC ACID AMIDE is a synthetic chemical compound with the molecular formula C8H11F3NO3. It is a derivative of the cyclopropane carboxylic acid amide family, and its structure includes a trifluoromethyl group and a methoxymethyl group attached to the cyclopropyl ring. N-METHOXYMETHYL-1-TRIFLUOROMETHYL-CYCLOPROPANECARBOXYLIC ACID AMIDE has potential applications in pharmaceutical research and drug development due to its unique structure and properties. It may have biological activity and pharmacological effects that make it useful for the treatment of specific medical conditions, but further research is needed to determine its full potential. Additionally, its chemical properties make it a valuable intermediate compound for the synthesis of other organic compounds. Overall, N-METHOXYMETHYL-1-TRIFLUOROMETHYL-CYCLOPROPANECARBOXYLIC ACID AMIDE has potential in various scientific and industrial applications, but its specific uses and effects have yet to be fully characterized.

Check Digit Verification of cas no

The CAS Registry Mumber 1011460-56-2 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,0,1,1,4,6 and 0 respectively; the second part has 2 digits, 5 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 1011460-56:
(9*1)+(8*0)+(7*1)+(6*1)+(5*4)+(4*6)+(3*0)+(2*5)+(1*6)=82
82 % 10 = 2
So 1011460-56-2 is a valid CAS Registry Number.

1011460-56-2Relevant articles and documents

Lead Optimization toward Proof-of-Concept Tools for Huntington's Disease within a 4-(1 H -Pyrazol-4-yl)pyrimidine Class of Pan-JNK Inhibitors

Wityak, John,McGee, Kevin F.,Conlon, Michael P.,Song, Ren Hua,Duffy, Bryan C.,Clayton, Brent,Lynch, Michael,Wang, Gwen,Freeman, Emily,Haber, James,Kitchen, Douglas B.,Manning, David D.,Ismail, Jiffry,Khmelnitsky, Yuri,Michels, Peter,Webster, Jeff,Irigoyen, MacArena,Luche, Michele,Hultman, Monica,Bai, Mei,Kuok, Iokteng D.,Newell, Ryan,Lamers, Marieke,Leonard, Philip,Yates, Dawn,Matthews, Kim,Ongeri, Lynette,Clifton, Steve,Mead, Tania,Deupree, Susan,Wheelan, Pat,Lyons, Kathy,Wilson, Claire,Kiselyov, Alex,Toledo-Sherman, Leticia,Beconi, Maria,Mu?oz-Sanjuan, Ignacio,Bard, Jonathan,Dominguez, Celia

, p. 2967 - 2987 (2015)

Through medicinal chemistry lead optimization studies focused on calculated properties and guided by X-ray crystallography and computational modeling, potent pan-JNK inhibitors were identified that showed submicromolar activity in a cellular assay. Using in vitro ADME profiling data, 9t was identified as possessing favorable permeability and a low potential for efflux, but it was rapidly cleared in liver microsomal incubations. In a mouse pharmacokinetics study, compound 9t was brain-penetrant after oral dosing, but exposure was limited by high plasma clearance. Brain exposure at a level expected to support modulation of a pharmacodynamic marker in mouse was achieved when the compound was coadministered with the pan-cytochrome P450 inhibitor 1-aminobenzotriazole. (Chemical Presented)

BICYCLIC KETONE COMPOUNDS AND METHODS OF USE THEREOF

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Page/Page column 53; 57, (2019/02/02)

The invention provides novel compounds having the general formula (I): (I) wherein R1, the A ring and the B ring are as described herein, pharmaceutical compositions including the compounds, and methods of using the compounds.

PYRAZOLE AMIDE DERIVATIVE

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Page/Page column 93, (2015/09/28)

The present invention relates to a novel compound having a function of inhibiting RORγ activity. The present invention also relates to pharmaceutical composition comprising the compound, a use of the compound in treating or preventing autoimmune diseases, inflammatory diseases, metabolic diseases, or cancer diseases.

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