1011470-64-6Relevant articles and documents
Malaria-infected mice are cured by oral administration of new artemisinin derivatives
Posner, Gary H.,Chang, Wonsuk,Hess, Lindsey,Woodard, Lauren,Sinishtaj, Sandra,Usera, Aimee R.,Maio, William,Rosenthal, Andrew S.,Kalinda, Alvin S.,D'Angelo, John G.,Petersen, Kimberly S.,Stohler, Remo,Chollet, Jacques,Santo-Tomas, Josefina,Snyder, Christopher,Rottmann, Matthias,Wittlin, Sergio,Brun, Reto,Shapiro, Theresa A.
, p. 1035 - 1042 (2008)
In four or five chemical steps from the 1,2,4-trioxane artemisinin, a new series of 23 trioxane dimers has been prepared. Eleven of these new trioxane dimers cure malaria-infected mice via oral dosing at 3 x 30 mg/kg. The clinically used trioxane drug sod