1011479-53-0Relevant articles and documents
An oral sphingosine 1-phosphate receptor 1 (S1P1) antagonist prodrug with efficacy in vivo: Discovery, synthesis, and evaluation
Angst, Daniela,Janser, Philipp,Quancard, Jean,Buehlmayer, Peter,Berst, Frederic,Oberer, Lukas,Beerli, Christian,Streiff, Markus,Pally, Charles,Hersperger, Rene,Bruns, Christian,Bassilana, Frederic,Bollbuck, Birgit
, p. 9722 - 9734 (2013/01/16)
A prodrug approach to optimize the oral exposure of a series of sphingosine 1-phosphate receptor 1 (S1P1) antagonists for chronic efficacy studies led to the discovery of (S)-2-{[3′-(4-chloro-2,5- dimethylphenylsulfonylamino)-3,5-dimethylbiphen
N-BIARYL (HETERO) ARYLSULPHONAMIDE DERIVATIVES USEFUL IN THE TREATMENT OF DISEASES MEDIATED BY LYMPHOCYTES INTERACTIONS
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Page/Page column 91, (2008/06/13)
A compound of formula (I) or a pharmaceutically acceptable salt or prodrug ester thereof: Formula (I) wherein the groups R1-R5, R10 and X1-X7 are as defined in the specification.