101152-94-7 Usage
Chemical Properties
Crystalline Solid
Uses
Different sources of media describe the Uses of 101152-94-7 differently. You can refer to the following data:
1. Antidepressant. A selective norepinephrine and serotonin reuptake inhibitor approved for the management of fibromyalgia.
2. antibacterial
General Description
Milnacipran, sold under the brand names Savella?, Ixel?, Dalcipran?, or Toledomin, is a serotonin-norepinephrine reuptake inhibitor (SNRI) used in the treatment of depression. In 2009, the US Food and Drug Administration (FDA) approved milnacipran for management of the chronic pain disorder fibromyalgia, making it only the third drug approved in the US for this indication besides duloxetine and pregabalin.
Biological Activity
Orally active 5-HT and noradrenalin re-uptake inhibitor (SNRI) (IC 50 values are 203 and 100 nM respectively) that displays no affinity at a range of other receptors. Causes adaptive changes to α 1 -adrenergic and 5-HT 2A serotonergic systems when administered repeatedly. Exhibits antidepressive and antinociceptive activities in vivo .
Biochem/physiol Actions
Serotonin and norepinephrine reuptake inhibitor (SNRI)
Check Digit Verification of cas no
The CAS Registry Mumber 101152-94-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,1,1,5 and 2 respectively; the second part has 2 digits, 9 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 101152-94:
(8*1)+(7*0)+(6*1)+(5*1)+(4*5)+(3*2)+(2*9)+(1*4)=67
67 % 10 = 7
So 101152-94-7 is a valid CAS Registry Number.
InChI:InChI=1/C15H22N2O.ClH/c1-3-17(4-2)14(18)15(10-13(15)11-16)12-8-6-5-7-9-12;/h5-9,13H,3-4,10-11,16H2,1-2H3;1H
101152-94-7Relevant articles and documents
An Efficient Synthesis of Milnacipran Hydrochloride via Reductive Amination of Aldehyde
Desireddy, Neha Reddy,Glory, Arava,Bhimireddy, Krishna Reddy,Kurra, Yadagiri,Reddy, Ram
, (2017)
An efficient synthesis of milnacipran hydrochloride has been accomplished. The important application of this paper is the reductive amination of aldehyde to primary amine with water soluble reagents. This method provides a high yield of primary amine as t
Drug intermediate as well as preparation and application thereof
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Paragraph 0009; 0065-0068, (2021/05/08)
The invention designs a drug intermediate III, and the structural formula of the drug intermediate III is shown in the specification.
Preparation method of 2-(aminomethyl)-N,N-diethyl-1-phenylcyclopropanecarboxamide and salt thereof
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Paragraph 0048-0050; 0051-0074, (2020/07/15)
The invention provides a novel method for preparing 2-(aminomethyl)-N,N-diethyl-1-phenylcyclopropanecarboxamide (milnacipran) and a salt thereof. The method comprises the following steps: reducing a compound with a structure represented by a formula (I) by using a reducing agent to obtain milnacipran with a structure represented by a formula (II), and salifying milnacipran to obtain milnacipran hydrochloride. The method provided by the invention effectively controls the generation of impurities, greatly improves the yield and the purity of the product, has the characteristics of environmentalprotection, safety and economy, is suitable for industrial production, and has a wide market application prospect.
