1011525-58-8

Basic information

• Product Name: 4-((1S,2R,6R,7R)-3,3-dioxido-3-thia-4-azatricyclo[5.2.1.02,6]dec-8-en-4-yl)-2-(trifluoromethyl)benzonitrile
• Synonyms: 4-((1S,2R,6R,7R)-3,3-dioxido-3-thia-4-azatricyclo[5.2.1.02,6]dec-8-en-4-yl)-2-(trifluoromethyl)benzonitrile
• CAS NO: 1011525-58-8
• Molecular Weight: 354.353
• Mol File: 1011525-58-8.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 4-((1S,2R,6R,7R)-3,3-dioxido-3-thia-4-azatricyclo[5.2.1.02,6]dec-8-en-4-yl)-2-(trifluoromethyl)benzonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 4-((1S,2R,6R,7R)-3,3-dioxido-3-thia-4-azatricyclo[5.2.1.02,6]dec-8-en-4-yl)-2-(trifluoromethyl)benzonitrile(1011525-58-8)
• EPA Substance Registry System: 4-((1S,2R,6R,7R)-3,3-dioxido-3-thia-4-azatricyclo[5.2.1.02,6]dec-8-en-4-yl)-2-(trifluoromethyl)benzonitrile(1011525-58-8)

Safety Data

• Hazardous Substances Data: 1011525-58-8(Hazardous Substances Data)

Upstream product

• 1011526-78-5 4-(1,1-dioxido-3-oxo-2(3H)-isothiazolyl)-2-(trifluoromethyl)benzonitrile 
• 542-92-7 cyclopenta-1,3-diene 

Downstream Products

• 1011525-62-4 4-((1S,2S,6R,7R,9S)-9-hydroxy-3,3-dioxido-3-thia-4-azatricyclo[5.2.1.02,6]dec-4-yl)-2-(trifluoromethyl)benzonitrile 
• 1011525-80-6 4-((1S,2R,6R,7R)-2-methyl-3,3-dioxido-3-thia-4-azatricyclo[5.2.1.02,6]dec-8-en-4-yl)-2-(trifluoromethyl)benzonitrile 
• 1011526-49-0 (1R,2R,6R,7S)-4-(4-cyano-3-(trifluoromethyl)phenyl)-3-thia-4-azatricyclo[5.2.1.02,6]decane-2-carbonyl chloride 3,3-dioxide 

Relevant articles and documents

[2.2.1]-Bicyclic sultams as potent androgen receptor antagonists

This letter describes the discovery, synthesis, SAR, and biological activity of [2.2.1]-bicyclic sultams as potent antagonists of the androgen receptor. Optimization of the series led to the identification of compound 25, which displayed robust pharmacody