1011529-10-4

Basic information

• Product Name: 4'-C-azido-2'-deoxy-2'-fluoro-beta-D-arabinocytidine
• Synonyms: 4'-C-azido-2'-deoxy-2'-fluoro-beta-D-arabinocytidine;2(1H)-PyriMidinone, 4-aMino-1-(4-C-azido-2-deoxy-2-fluoro-b-D-arabinofuranosyl)-;4-Amino-1-(4-C-azido-2-deoxy-2-fluoro-beta-D-arabinofuranosyl)-2(1H)-pyrimidinone;RO 0622;4'-C-Azido-2'-deoxy-2'-fluoro-b-D-arabinocytidine
• CAS NO: 1011529-10-4
• Molecular Formula: C9H11FN6O4
• Molecular Weight: 286.2198432
• EINECS: -0
• Mol File: 1011529-10-4.mol
• Article Data: 5

Chemical Properties

• Melting Point: 99.0-100.0℃
• Appearance: /
• CAS DataBase Reference: 4'-C-azido-2'-deoxy-2'-fluoro-beta-D-arabinocytidine(CAS DataBase Reference)
• NIST Chemistry Reference: 4'-C-azido-2'-deoxy-2'-fluoro-beta-D-arabinocytidine(1011529-10-4)
• EPA Substance Registry System: 4'-C-azido-2'-deoxy-2'-fluoro-beta-D-arabinocytidine(1011529-10-4)

Safety Data

• Hazardous Substances Data: 1011529-10-4(Hazardous Substances Data)

Usage

General Description

4'-C-azido-2'-deoxy-2'-fluoro-beta-D-arabinocytidine, also known as AFdC or RX-3117, is a chemical compound that belongs to the class of nucleoside analogs. It is designed to inhibit the activity of DNA and RNA synthesis by targeting and inhibiting the enzyme ribonucleotide reductase, thereby preventing the proliferation of cancer cells. AFdC has shown promising antitumor activity in preclinical studies and is being investigated as a potential treatment for various types of cancer, including pancreatic, lung, and bladder cancers. Additionally, AFdC has been shown to have activity against viruses such as hepatitis B and C. Clinical studies are ongoing to evaluate the safety and efficacy of AFdC in cancer patients.

Upstream product

• 1333126-30-9 1-(4-azido-2-deoxy-2-fluoro-3-O-benzoyl-5-O-(3-chlorobenzoyl)-β-D-arabinofuranosyl)uracil 
• 1030595-44-8 C₁₁H₁₃FN₆O₅ 

Downstream Products

• 1352801-00-3 1-[4'-(4-ethylphenyl-1,2,3-triazol-1-yl)-2'-deoxy-2'-fluoro-β-D-arabinofuranosyl]cytosine 
• 1352800-99-7 1-[4'-(4-methylphenyl-1,2,3-triazol-1-yl)-2'-deoxy-2'-fluoro-β-D-arabinofuranosyl]cytosine 
• 1352800-98-6 1-[4'-(4-phenyl-1,2,3-triazol-1-yl)-2'-deoxy-2'-fluoro-β-D-arabinofuranosyl]cytosine 

Relevant articles and documents

3-methyl uridine and 4-methyl cytidine nucleoside compound, synthetic method and its pharmaceutical use

The invention discloses a 3-methyluridine and 4-methylcytidine nucleosides compound and a synthesis method and pharmaceutical application thereof, belonging to the field of medicinal chemistry. The compound has a structural formula as shown in the specification. The compound has the effects of simultaneously modifying sugar rings and basic groups, increasing the activity of the compound and reducing the toxicity, provides a good application prospect for development of like medicines and can be applied to preparation of anti-HBV (Hepatitis B virus) medicines. The synthesis method is simple and feasible and provides conditions for mass synthesis of the compound.

2'-FLUORO-4'-SUBSTITUTED NUCLEOSIDES, THE PREPARATION AND USE

The present invention provides 2'-fluorine-4'-substituted-nucleoside analogues or their pro-drugs or 5'-phosphate esters (including the pro-drugs of the 5'-phosphate esters), preparation methods and uses thereof. The compounds have the general formula as follows: wherein: R = CH3, CH, N3, C≡CH; R' = H, F; X = F, OH, NH2; Y = H, CH3, F, OH, NH2 The compounds are used in the synthesis of drugs for the treatment of virus infection, especially for the treatment of HBV, HCV or HIV infection.

2',4'-SUBSTITUTED NUCLEOSIDES AS ANTIVIRAL AGENTS

Embodiments of the invention are to compounds of formulae (A), (A'), methods, and compositions for use in the treatment of viral infections. More specifically embodiments of the invention aur 2 ', 4 ' -substituted nucleoside compounds useful for the treat