101154-75-0

Upstream product

• 608-68-4 dimethyl L-tartrate 
• 71573-93-8 1-(4-chlorophenyl)-3-methyl-butan-1-one 

Downstream Products

• 101154-77-2 (4R,5R)-2-((R)-1-Bromo-2-methyl-propyl)-2-(4-chloro-phenyl)-[1,3]dioxolane-4,5-dicarboxylic acid dimethyl ester 
• 101154-76-1 (4R,5R)-2-((S)-1-Bromo-2-methyl-propyl)-2-(4-chloro-phenyl)-[1,3]dioxolane-4,5-dicarboxylic acid dimethyl ester 

Relevant academic research and scientific papers

Tartaric Acid, an Efficient Chiral Auxiliary: New Asymmetric Synthesis of 2-Alkyl-2-arylacetic Acids

A highly enantioselective synthesis of 2-alkyl-2-arylacetic acids, an important class of antiinflammatory agents, based on a new diastereoselective α-bromination of homochiral acetals 1 and on the stereospecific silver-promoted rearrangement of the corresponding homochiral α-bromo acetals 2 and 3, is reported.The new methodology represents a meaningful example of the use of tartaric acid as efficient and economic chiral auxiliary.The asymmetric bromination of 1 is of general character and occurs with very high diastereoselectivity, even at room temperature; a mechanism for the new reaction is proposed.The overall process has been successfully applied to the preparation of enantiomerically pure 2-alkyl-2-arylacetic acids, among them (2S)-(+)-2-(6-methoxy-2-naphthyl)propanoic acid (Naproxen)