101156-38-1Relevant articles and documents
Bisindole alkaloids condensed with a cyclopropane ring, part 1. 14,15-cyclopropanovinblastine and - Vincristine
Keglevich, Peter,Hazai, Laszlo,Dubrovay, Zsofia,Dekany, Miklos,Szantay Jr., Csaba,Kalaus, Gyoergy
, p. 653 - 668 (2014/04/03)
A new type of vinblastine and vincristine derivatives was synthesized. The carbon carbon double bond in position 14 and 15 of the vindoline ring was cyclopropanated. In the course of the synthetic work 14,15-cyclopropanovindoline was coupled with catharanthine, resulting in the cyclopropanated anhydrovinblastine as a key intermediate to 14,15-cyclopropano-vinblastine and - vincristine.