1011711-60-6

Basic information

• Product Name: Ethanone, 1-(6-broMo-1H-pyrrolo[2,3-b]pyridin-3-yl)-
• Synonyms: Ethanone, 1-(6-broMo-1H-pyrrolo[2,3-b]pyridin-3-yl)-;1-(6-bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)ethanone
• CAS NO: 1011711-60-6
• Molecular Formula: C₉H₇BrN₂O
• Molecular Weight: 239.06868
• Mol File: 1011711-60-6.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Ethanone, 1-(6-broMo-1H-pyrrolo[2,3-b]pyridin-3-yl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Ethanone, 1-(6-broMo-1H-pyrrolo[2,3-b]pyridin-3-yl)-(1011711-60-6)
• EPA Substance Registry System: Ethanone, 1-(6-broMo-1H-pyrrolo[2,3-b]pyridin-3-yl)-(1011711-60-6)

Safety Data

• Hazardous Substances Data: 1011711-60-6(Hazardous Substances Data)

Usage

General Description

Ethanone, 1-(6-bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)- is a chemical compound that belongs to the class of ketones and contains a pyrrolopyridine moiety. It is a brominated derivative of pyrrolopyridine, which is commonly used in the field of medicinal chemistry for the development of pharmaceutical drugs. The presence of the bromine atom in this compound contributes to its chemical properties and potential biological activities. Ethanone, 1-(6-bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)- may have applications in drug discovery and development due to its unique structure and potential interactions with biological targets. Further research and studies may be needed to fully understand the properties and potential uses of Ethanone, 1-(6-bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)-.

Upstream product

• 108-24-7 acetic anhydride 
• 143468-13-7 6-Bromo-1H-pyrrolo<2,3-b>pyridine 

Downstream Products

• 1011711-64-0 3-acetyl-1-benzenesulfonyl-6-bromo-1H-pyrrolo[2,3-b]pyridine 

Relevant articles and documents

Meriolins (3-(pyrimidin-4-yl)-7-azaindoles): Synthesis, kinase inhibitory activity, cellular effects, and structure of a CDK2/Cyclin A/meriolin complex

We report the synthesis and biological characterization of 3-(pyrimidin-4-yl)-7-azaindoles (meriolins), a chemical hybrid between the natural products meridianins and variolins, derived from marine organisms. Meriolins display potent inhibitory activities toward cyclin-dependent kinases (CDKs) and, to a lesser extent, other kinases (GSK-3, DYRK1A). The crystal structures of 1e (meriolin 5) and variolin B (Bettayeb, K.; Tirado, O. M.; Marionneau-Lambert, S.; Ferandin, Y.; Lozach, O.; Morris, J.; Mateo-Lozano, S.; Drückes, P.; Sch?chtele, C.; Kubbutat, M.; Liger, F.; Marquet, B.; Joseph, B.; Echalier, A.; Endicott, J.; Notario, V.; Meijer, L. Cancer Res. 2007, 67, 8325-8334) in complex with CDK2/cyclin A reveal that the two inhibitors are orientated in very different ways inside the ATP-binding pocket of the kinase. A structure-activity relationship provides further insight into the molecular mechanism of action of this family of kinase inhibitors. Meriolins are also potent antiproliferative and proapoptotic agents in cells cultured either as monolayers or in spheroids. Proapoptotic efficacy of meriolins correlates best with their CDK2 and CDK9 inhibitory activity. Meriolins thus constitute a promising class of pharmacological agents to be further evaluated against the numerous human diseases that imply abnormal regulation of CDKs including cancers, neurodegenerative disorders, and polycystic kidney disease.