1011758-03-4Relevant articles and documents
Refining method of quetiapine fumarate
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Paragraph 0028-0031, (2021/01/29)
The invention provides a refining method of quetiapine hemifumarate. The refining method comprises the following steps: feeding crude quetiapine hemifumarate in a refining solvent, adding certain amount of fumaric acid, performing backflow pulping, cooling, crystallizing, filtering and drying to obtain a finished quetiapine hemifumarate product. Through adding the certain amount of fumaric acid, the refining yield and the refining efficiency can be respectively and effectively increased and improved. The invention further provides an impurity synthesis method.