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1011794-41-4

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1011794-41-4 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1011794-41-4 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,0,1,1,7,9 and 4 respectively; the second part has 2 digits, 4 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 1011794-41:
(9*1)+(8*0)+(7*1)+(6*1)+(5*7)+(4*9)+(3*4)+(2*4)+(1*1)=114
114 % 10 = 4
So 1011794-41-4 is a valid CAS Registry Number.

1011794-41-4Downstream Products

1011794-41-4Relevant articles and documents

A convenient one-pot synthesis of thiazol-2-imines: application in the construction of pifithrin analogues

Murru, Siva,Singh,Kavala, Veerababurao,Patel, Bhisma K.

, p. 1931 - 1942 (2008/09/17)

For the first time a reaction intermediate has been isolated giving further insight into the mechanism of thiazol-2-imine formation. The first step of the reaction requires a basic medium, while the second step is an acid mediated E1 elimination reaction. An efficient one-pot synthesis of substituted thiazol-2-imines have been achieved by the condensation of carbonyl compounds with thioureas and 1,3-disubstituted thioureas using 1,1′-(ethane-1,2-diyl)dipyridinium bistribromide (EDPBT). Unsymmetrical 1,3-disubstituted thioureas give regioselective products with symmetrical ketones, which are mainly governed by the pKas of NH protons of thiourea, whereas symmetrical 1,3-disubstituted thioureas give regioselective products with symmetrical carbonyl compounds owing to the regioselective bromination of ketones. The methodology is extended to access novel neurodegenerative drug candidate pifithrin-α analogues in good yields in shorter reaction time. This method is simple, versatile and is applicable for different 1,3-disubstituted thioureas as well as a range of carbonyl compounds.

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