1011832-55-5

Basic information

• Product Name: 2-methyl-7-(4-methylphenoxy)-5-nitroquinazoline-4(3H)-one
• CAS NO: 1011832-55-5
• Molecular Weight: 311.297
• Mol File: 1011832-55-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-methyl-7-(4-methylphenoxy)-5-nitroquinazoline-4(3H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 2-methyl-7-(4-methylphenoxy)-5-nitroquinazoline-4(3H)-one(1011832-55-5)
• EPA Substance Registry System: 2-methyl-7-(4-methylphenoxy)-5-nitroquinazoline-4(3H)-one(1011832-55-5)

Safety Data

• Hazardous Substances Data: 1011832-55-5(Hazardous Substances Data)

Upstream product

• 890092-86-1 2-methyl-5,7-dinitroquinazoline-4(3H)-one 
• 106-44-5 p-cresol 

Relevant articles and documents

Synthetic utilization of polynitroaromatic compounds. 6. Remarkable regioselectivity in nucleophilic displacement of aromatic nitro groups with amines

(Chemical Equation Presented) 5,7-Dinitroquinazoline-4-ones undergo nucleophilic displacement of a nitro group with N-, S-, and O-nucleophiles. In contrast to previously studied dinitro-substituted benzoannulated five- and seven-membered heterocycles (where a high degree of selectivity was observed), these quinazolines mostly yield mixtures of regioisomeric substitution products. At the same time, primary and secondary amines react selectively to afford 5-aminoquinazolones (peri-substitution). A similar effect is observed for some other polynitroaromatic compounds with adjacent nitro and carbonyl groups. This phenomenon is attributed to a stabilization of the intermediate peri-σ-complex by intramolecular hydrogen bond N+-H...O=C.