101184-73-0

Basic information

• Product Name: 2-(4-Bromophenyl)-2-methylpropanenitrile
• Synonyms: 2-(4-BROMOPHENYL)-2-METHYLPROPANENITRILE;2-(4-BROMOPHENYL)-2-METHYLPROPIONITRILE;4-Bromo-alpha,alpha-dimethylbenzeneacetonitrile;P-Bromo a,a-Dimethyl Phenyl Acetonitrile;2-(4-Bromophenyl)-2-methylpropanenitrile 98%;ALPHA,ALPHA-DIMETHYL-4-BROMOPHENYLACETONITRILE;α,α-Dimethyl 4-bromophenylacetonitrile;2-(4-Bromophenyl)-2-methylpropanenitrile-2
• CAS NO: 101184-73-0
• Molecular Formula: C₁₀H₁₀BrN
• Molecular Weight: 224.1
• Product Categories: blocks;Bromides;Carboxes
• Mol File: 101184-73-0.mol
• Article Data: 33

Chemical Properties

• Melting Point: 110-113
• Boiling Point: 299.8 °C at 760 mmHg
• Flash Point: 135.1 °C
• Appearance: /
• Density: 1.352g/cm³
• Vapor Pressure: 0.00117mmHg at 25°C
• Refractive Index: 1.543
• Storage Temp.: Keep Cold
• CAS DataBase Reference: 2-(4-Bromophenyl)-2-methylpropanenitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-Bromophenyl)-2-methylpropanenitrile(101184-73-0)
• EPA Substance Registry System: 2-(4-Bromophenyl)-2-methylpropanenitrile(101184-73-0)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 22-51
• Hazardous Substances Data: 101184-73-0(Hazardous Substances Data)

Usage

General Description

2-(4-Bromophenyl)-2-methylpropanenitrile, also known as bromazepam, is a chemical compound with the molecular formula C10H10BrN. It is a pale yellow solid that is primarily used as an intermediate in the synthesis of pharmaceuticals and other organic compounds. Bromazepam is a nitrile derivative and contains a benzene ring substituted with a bromine atom and a methyl group. It is commonly used in the production of drugs with sedative, hypnotic, and anxiolytic properties, and is also used in organic synthesis as a building block in the production of various other organic compounds. Bromazepam is considered to be a hazardous chemical, and proper safety precautions should be taken when handling and storing it.

InChI:InChI=1/C10H10BrN/c1-10(2,7-12)8-3-5-9(11)6-4-8/h3-6H,1-2H3

Upstream product

• 16532-79-9 4-Bromophenylacetonitrile 
• 74-88-4 methyl iodide 
• 119072-55-8 tert-butylisonitrile 
• 586-61-8 4-iso-propylbromobenzene 

Downstream Products

• 32454-16-3 2-(4-bromophenyl)-2-methyl-propionaldehyde 
• 252022-33-6 2-[4-(4-Hydroxy-1-butynyl)phenyl]isobutyronitrile 
• 1784426-29-4 7-bromo-4,4-dimethyl-3,4-dihydroisoquinolin-1(2H)-one 
• 115279-57-7 2-(4-aminophenyl)-2-methylpropionitrile 
• 1082066-30-5 2-methyl-2-[4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-propionitrile 
• 1360549-57-0 5-(4-{1-methyl-1-[5-(1-methyl-1H-pyrazol-4-yl)-[1,2,4]oxadiazol-3-yl]ethyl}phenyl)pyrimidin-2-ylamine 
• 1360552-06-2 2-[4-(2-aminopyrimidin-5-yl)phenyl]-N-hydroxyisobutyramidine 
• 1309580-85-5 ethyl 4-(1-cyano-1-methyl-ethyl)benzoate 
• 129488-74-0 4-(1-cyano-1-methylethyl)benzoic acid 
• 850568-67-1 [4-(1-cyano-1-methylethyl)phenyl]boronic acid 
• 1431616-21-5 6-(4-(2-cyanopropan-2-yl)phenyl)nicotinonitrile 
• 1430217-71-2 N-(2-(4-bromophenyl)-2-methylpropyl)formamide 
• 1394050-39-5 C₂₅H₃₁NO₄ 
• 1432502-60-7 C₂₅H₂₉NO₄ 

Relevant articles and documents

Meta-selective C-H functionalization using a nitrile-based directing group and cleavable Si-tether

A nitrile-based template that enables meta-selective C-H bond functionalization was developed. The template is applicable to a range of substituted arenes and tolerates a variety of functional groups. The directing group uses a silicon atom for attachment

Palladium-Catalyzed Distal m-C-H Functionalization of Arylacetic Acid Derivatives

Herein, we present m-C-H olefination on derivatives of phenylacetic acids by tethering with a simple nitrile-based template through palladium catalysis. Notably, the versatility of the method is evaluated with a wide range of phenylacetic acid derivatives for obtaining the meta-olefination products in fair to excellent yields with outstanding selectivities under mild conditions. Significantly, the present strategy is successfully exemplified for the synthesis of drugs/natural product analogues (naproxen, ibuprofen, paracetamol, and cholesterol).

Cobalt-catalyzed C[sbnd]H activation/C[sbnd]O formation: Synthesis of benzofuranones

Herein, C[sbnd]H activation/C[sbnd]O formation reaction using novel cobalt catalytic system is reported. This reaction was given benzofuranones in moderate to excellent yields at room-temperature under air reaction conditions. The introduced strategy is efficient and low-cost method to synthesized benzofuranones from α,α-disubstitution acetic acid.