101204-49-3

Basic information

• Product Name: 2'-DEOXY-N6-METHYLADENOSINE 3',5'-BISPHOSPHATE TETRAAMMONIUM SALT
• Synonyms: MRS 2179 TETRASODIUM SALT;2'-DEOXY-N6-METHYLADENOSINE 3',5'-BISPHOSPHATE TETRASODIUM SALT;2'-DEOXY-N6-METHYLADENOSINE 3',5'-BISPHOSPHATE TETRAAMMONIUM SALT;MRS2179tetraammoniumsalt;MRS2179 hydrate ammonium salt;MRS 2179 ammonium salt hydrate;MRS2179 ammonium salt;[2-[(hydroxy-oxidophosphoryl)oxymethyl]-5-(6-methylaminopurin-9-yl)oxolan-3-yl] hydrogen phosphate
• CAS NO: 101204-49-3
• Molecular Formula: C11H29N9O9P2
• Molecular Weight: 493.35
• Mol File: 101204-49-3.mol
• Article Data: 0

Chemical Properties

• Boiling Point: 821.6±75.0 °C(Predicted)
• Appearance: /
• Density: 2.15±0.1 g/cm3(Predicted)
• Storage Temp.: −20°C
• Solubility: DMSO: 1.1 mg/mL
• PKA: 1.83±0.10(Predicted)
• CAS DataBase Reference: 2'-DEOXY-N6-METHYLADENOSINE 3',5'-BISPHOSPHATE TETRAAMMONIUM SALT(CAS DataBase Reference)
• NIST Chemistry Reference: 2'-DEOXY-N6-METHYLADENOSINE 3',5'-BISPHOSPHATE TETRAAMMONIUM SALT(101204-49-3)
• EPA Substance Registry System: 2'-DEOXY-N6-METHYLADENOSINE 3',5'-BISPHOSPHATE TETRAAMMONIUM SALT(101204-49-3)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 101204-49-3(Hazardous Substances Data)

Usage

Uses

MRS 2179 ammonium salt hydrate has been used as a P2Y1 receptor antagonist in porcine coronary small arteries, endothelial cells, and hippocampal astrocytes.

Biological Activity

A competitive antagonist at P2Y 1 receptors (K B = 100 nM). Selective over P2X 1 (IC 50 = 1.15 μ M), P2X 3 (IC 50 = 12.9 μ M), P2X 2 , P2X 4 , P2Y 2 , P2Y 4 and P2Y 6 receptors.

Biochem/physiol Actions

MRS 2179 resists localized venous thrombosis and is useful in treating thrombotic syndromes due to its platelet aggregation inhibition functionality.