1012084-56-8

Basic information

• Product Name: 2-METHYLPYRIDINE-3-BORONIC ACID PINACOL ESTER
• Synonyms: 2-METHYLPYRIDINE-3-BORONIC ACID PINACOL ESTER;Pyridine, 2-methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-;2-Methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine, 2-(2-Methylpyridin-3-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
• CAS NO: 1012084-56-8
• Molecular Formula: C₁₂H₁₈BNO₂
• Molecular Weight: 219.08782
• Mol File: 1012084-56-8.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 311.6 °C at 760 mmHg
• Flash Point: 142.2 °C
• Appearance: /
• Density: 1.02 g/cm³
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 5.94±0.12(Predicted)
• CAS DataBase Reference: 2-METHYLPYRIDINE-3-BORONIC ACID PINACOL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 2-METHYLPYRIDINE-3-BORONIC ACID PINACOL ESTER(1012084-56-8)
• EPA Substance Registry System: 2-METHYLPYRIDINE-3-BORONIC ACID PINACOL ESTER(1012084-56-8)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 1012084-56-8(Hazardous Substances Data)

Usage

General Description

2-Methylpyridine-3-boronic acid pinacol ester is a chemical compound that is commonly used in organic synthesis as a building block for the construction of various pharmaceuticals and agrochemicals. It is a boronic acid derivative, which makes it a useful reagent for Suzuki-Miyaura coupling reactions, allowing for the formation of carbon-carbon bonds. 2-Methylpyridine-3-boronic acid pinacol ester is also used in the preparation of heterocyclic compounds and as a catalyst in various chemical reactions. It is important in the field of organic chemistry for its versatility in forming complex molecules and its role in the development of new drug candidates and functional materials.

InChI:InChI=1S/C12H18BNO2/c1-9-10(7-6-8-14-9)13-15-11(2,3)12(4,5)16-13/h6-8H,1-5H3

Upstream product

• 73183-34-3 bis(pinacol)diborane 
• 38749-79-0 3-bromo-2-picoline 

Downstream Products

• 1951408-58-4 N-((5-fluoro-2,3-dihydrobenzofuran-4-yl)methyl)-8-(2-methylpyridin-3-yl)-[1,2,4]triazolo[4,3-c]pyrimidin-5-amine 
• 1620294-42-9 (5-((2-(2-methylpyridin-3-yl)phenoxy)methyl)-4,5-dihydroisoxazol-3-yl)methanamine hydrochloride 
• 1620294-40-7 tert-butyl ((5-((2-(2-methylpyridin-3-yl)phenoxy)methyl)-4,5-dihydroisoxazol-3-yl)methyl)carbamate 
• 1448015-73-3 (6-Methylpyridin-2-yl)-{4-[4-(2-methylpyridin-3-yl)phenyl]thiazol-2-yl}amine trifluoroacetate salt 
• 1448015-76-6 cyclopropanecarboxylic acid {4-[4-(2-methylpyridin-3-yl)phenyl]thiazol-2-yl}amide 

Relevant articles and documents

Synthesis of biaryls through a one-pot tandem borylation/Suzuki-Miyaura cross-coupling reaction catalyzed by a palladacycle

The tricyclohexylphosphane adduct of cyclopalladated ferrocenylimine I exhibited high catalytic activity in the one-pot borylation/Suzuki-Miyaura coupling (BSC) reaction with low catalyst loading (2 mol-%). Various biaryls were obtained in good to excellent yields for 37 examples. This process was applied to aryl and heteroaryl halides (Br and Cl) containing a variety of functional groups and did not require an excess amount of phosphane ligand and the addition of the palladium catalyst in the second step. Cyclopalladated ferrocenylimine I exhibited high catalytic activity in the borylation/Suzuki- Miyaura coupling (BSC) reaction with low catalyst loading. Various unsymmetrical biaryls were obtained ingood to excellent yields in one pot. This protocol was applied to aryl and heteroaryl halides (Br and Cl) containing a variety of functional groups without adding catalyst in the second step. Copyright

Pyrido[3,2-E]Pyrazines, Process For Preparing The Same, And Their Use As Inhibitors Of Phosphodiesterase 10

The invention relates to pyrido[3,2-e]pyrazines, to processes for preparing them, to pharmaceutical compositions which comprise these compounds and to the pharmaceutical use of these compounds, which are inhibitors of phosphodiesterase 10, as active compounds for treating central nervous system disorders, obesity, and metabolic disorders.