101210-80-4

Upstream product

• 21878-65-9 α-Methyl-N-phthaloylphenylalanin 
• 101210-79-1 2-(2-carboxybenzamido)-2-methyl-3-phenylpropanoic acid 
• 85-44-9 phthalic anhydride 
• 1132-26-9 2-methyl-3-phenylalanine 
• 64298-85-7 methyl-2-benzylideneamino-2-methyl-3-phenylpropanoate 
• 101210-78-0 methyl 2-(2-carboxybenzamido)-2-methyl-3-phenylpropanoate 
• 64282-11-7 methyl 2-(phenylmethyl)-2-aminopropionate 

Downstream Products

• 101210-82-6 1-chloro-3-methyl-4-phenyl-3-phthalimidobutan-2-one 
• 101210-83-7 1-hydroxy-3-methyl-4-phenyl-3-phthalimidobutan-2-one 
• 101210-84-8 3-amino-1-hydroxy-3-methyl-4-phenylbutan-2-one hydrochloride 
• 101211-00-1 2-amino-6-(2-benzyl-4-hydroxy-3-oxobutan-2-ylamino)-5-nitropyrimidin-4(3H)-one 
• 101210-99-5 2-amino-6-(2-benzyl-4-hydroxy-3-oxobutan-2-ylamino)-5-nitropyrimidin-4(3H)-one semicarbazone 
• 101231-99-6 3-amino-1-hydroxy-3-methyl-4-phenylbutan-2-one semicarbazone hydrochloride 
• 101210-81-5 1-diazo-3-methyl-4-phenyl-3-phthalimodobutan-2-one 

Relevant academic research and scientific papers

Intramolecular Friedel-Crafts Acylation of N-Phthaloyl-Substituted Arylalanyl and Homophenylalanyl Chlorides

N-Phthaloyl-protected arylalanyl and homophenylalanyl chlorides 5 are acylated intramolecularly to 2-phthalimido-1-indanones 6 and -1-tetralone (6d) with AlCl3 (two-fold molar amounts) or catalytic amounts of FeCl3.The cycloacylation to the tetralone 6d with AlCl3 or FeCl3 proceeds without racemisation in very good yields, whereas the cycloacylation to the indanone 6a with FeCl3 gives rise to racemisation.Mixed anhydrides 11 of N-phthaloyl-α-amino acids and trifluoromethanesulfonate were prepared from the N-phthaloylamino acid chlorides and silver triflate.Acylation of arenes 12 with 11a as well as cycloaddition of (S)-O-methyl-N-phthaloyltyrosine triflate can be achieved without racemisation and without a catalyst.

Specific Inhibitors in Vitamin Biosynthesis. Part 7. Syntheses of Blocked 7,8-Dihydropteridines via &α-Amino Ketones

The synthesis of 15 blocked 7,8-dihydropteridines is described in which the pyrazine ring is built from a derivative of an α-amino ketone.Three routes to the amino ketones based upon amino acids, nitrosyl chloride addition to alkenes, and nitro alcohols are discussed.The compounds synthesised are inhibitors of 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase , an enzyme in the pathway leading to dihydrofolate, and the inhibitory potencies of the compounds are discussed in the light of a hypothetical active site model for the enzyme.