1012104-68-5 Usage
Biological Activity
irak inhibitor 4 is an inhibitor of interleukin- 1 receptor-associated kinase [1].irak-4 belongs to interleukin-1 receptor-associated kinase, which are key components in the signal transduction pathways. irak-4 is an essential signal transducer downstream of interleukin-1 receptor (il-1r), interleukin-18 receptor (il-18r) and toll-like receptors (tlrs). inhibition of irak-4 can modulate its function, thus toning down inflammatory responses. irak inhibitor 4 is an indazole inhibitor. as inhibitors of irak-4, imidazo[1,2-b]pyridazines and indazoles are used for treatment of some inflammatory, cell proliferative and immune-related disorders [1].
references
[1] zhulun wang, holger wesche, tracey stevens, nigel walker and wen-chen yeh. irak-4 inhibitors for inflammation. current topics in medicinal chemistry. 2009, 9: 724-737.
Check Digit Verification of cas no
The CAS Registry Mumber 1012104-68-5 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,0,1,2,1,0 and 4 respectively; the second part has 2 digits, 6 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 1012104-68:
(9*1)+(8*0)+(7*1)+(6*2)+(5*1)+(4*0)+(3*4)+(2*6)+(1*8)=65
65 % 10 = 5
So 1012104-68-5 is a valid CAS Registry Number.
1012104-68-5Relevant articles and documents
Indazole derivatives as modulators of interleukin-1 receptor-associated kinase
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Page/Page column 19, (2011/07/06)
The present invention relates to modulators of IRAK kinases of formula (I) and provides compositions comprising such modulators, as well as methods therewith for treating IRAK-mediated or IRAK-associated conditions or diseases.