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101219-68-5 Usage

Chemical Properties

clear colorless to pale yellow liquid

Uses

(R)-1-(4-FLUOROPHENYL)ETHANOL is a useful research chemical.

Check Digit Verification of cas no

The CAS Registry Mumber 101219-68-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,1,2,1 and 9 respectively; the second part has 2 digits, 6 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 101219-68:
(8*1)+(7*0)+(6*1)+(5*2)+(4*1)+(3*9)+(2*6)+(1*8)=75
75 % 10 = 5
So 101219-68-5 is a valid CAS Registry Number.
InChI:InChI=1/C3H4Br2ClF/c1-3(5,7)2(4)6/h2H,1H3

101219-68-5 Well-known Company Product Price

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  • Aldrich

  • (685844)  (R)-4-Fluoro-α-methylbenzylalcohol  97%

  • 101219-68-5

  • 685844-250MG

  • 547.56CNY

  • Detail
  • Aldrich

  • (685844)  (R)-4-Fluoro-α-methylbenzylalcohol  97%

  • 101219-68-5

  • 685844-1G

  • 1,428.57CNY

  • Detail

101219-68-5SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name (R)-(+)-4-Fluoro-alpha-methylbenzyl alcohol

1.2 Other means of identification

Product number -
Other names (R)-1-(4-Fluorophenyl)ethanol

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:101219-68-5 SDS

101219-68-5Relevant articles and documents

Sugar-monophosphite ligands applied to the asymmetric Ni-catalyzed trialkylaluminum addition to aldehydes

Alegre, Sabina,Dieguez, Montserrat,Pmies, Oscar

, p. 834 - 839 (2011)

A series of readily available sugar-based phosphite ligands were applied to the Ni-catalyzed asymmetric trialkylaluminum additions to aldehydes. The ability of the catalysts to transfer chiral information to the product could be tuned by choosing suitable ligand components (configuration at C-3 of the furanoside backbone; the steric hindrance of the substituent at C-3 and the substituents/configuration of the biaryl phosphite moieties). Good enantioselectivities (ee's up to 84%) were obtained for several aryl aldehydes using several organoaluminum sources.

Synthesis and biological evaluation of disubstituted pyrimidines as selective 5-HT2C agonists

Kim, Juhyeon,Kim, Yoon Jung,Londhe, Ashwini M.,Pae, Ae Nim,Choo, Hyunah,Kim, Hak Joong,Min, Sun-Joon

, (2019)

Here, we describe the synthesis of disubstituted pyrimidine derivatives and their biological evaluation as selective 5-HT2C agonists. To improve selectivity for 5-HT2C over other subtypes, we synthesized two series of disubstituted pyrimidines with fluorophenylalkoxy groups at either the 5-position or 4-position and varying cyclic amines at the 2-position. The in vitro cell-based assay and binding assay identified compounds 10a and 10f as potent 5-HT2C agonists. Further studies on selectivity to 5-HT subtypes and drug-like properties indicated that 2,4-disubstituted pyrimidine 10a showed a highly agonistic effect on the 5-HT2C receptor, with excellent selectivity, as well as exceptional drug-like properties, including high plasma and microsomal stability, along with low CYP inhibition. Thus, pyrimidine 10a could be considered a viable lead compound as a 5-HT2C selective agonist.

Cheap and environmentally sustainable stereoselective arylketones reduction by Lactobacillus reuteri whole cells

Perna,Ricci,Scilimati,Mena,Pisano,Palmieri,Agrimi,Vitale

, p. 29 - 37 (2016)

Various Lactobacillus reuteri strains were investigated as whole cell catalysts for the bioreduction of acetophenone into optically active (R)-1-phenylethanol. L. reuteri DSM 20016 strain gave an almost complete substrate conversion, in a short reaction time and enantiomeric excess up to 99%. The acetophenone bioreduction was used as a model reaction to optimize temperature and reducing equivalent source (glucose, lactose, cheese way and lignocellulosic hydrolysates) to accomplish the biotransformation. The reduction of acetophenones into optically active (R)-1-arylethanols was also exploited to study L. reuteri DSM 20016 substrate specificity. In most of the cases, optically active (R)-1-arylethanols have been obtained with both excellent chemical and optical yields and with (R)-enantiopreference, through a cheap, simple and efficient process.

Construction of a chiral macromolecular catalyst in hollow silica nanoreactors for efficient and recyclable asymmetric catalysis

Jing, Lingyan,Zhang, Xiaoming,Guan, Ruqun,Yang, Hengquan

, p. 2304 - 2311 (2018)

The entrapment method is a fascinating pathway to convert homogeneous into heterogeneous catalysts. However, the types of entrapped catalysts and available supports are still limited because of the strict requirements of this method. Here, we reported a novel strategy for achieving efficient entrapment of a chiral homogeneous catalyst by forming macromolecular polymers in the cavity of hollow silica nanoreactors. Specifically, through in situ polymerization of the chiral ligand (1R,2R)-N1-(4-vinylbenzenesulfonyl)-1,2-diphenylethane-1,2-diamine (VBS-DPEN) with styrene followed by coordination of the metal precursor [Cp?RhCl2]2 (Cp? = pentamethylcyclopentadiene), a chiral solid catalyst with a confined macromolecular polymer was obtained. In the aqueous asymmetric transfer hydrogenation (ATH) of ketones, such a catalyst exhibited much better activity (TOF 991 vs. 724 h-1) and similar enantioselectivity (94% ee) compared with its homogeneous counterpart. This excellent activity can be attributed to the combination of the hollow mesoporous structure, unique hydrophobic@hydrophilic surface properties and semi-free state of the macromolecular catalyst. Moreover, the solid catalyst exhibits good recyclability, which is much better than the pure macromolecular polymer catalyst. Our studies not only provide an excellent heterogeneous asymmetric catalyst but also demonstrate that the pathway for confining macromolecules could be used as an efficient scaffold for the synthesis of entrapped catalysts.

Construction of hydrogen-bonded ternary organic crystals derived from L -tartaric acid and their application to enantioseparation of secondary alcohols

Kodama, Koichi,Sekine, Eriko,Hirose, Takuji

, p. 11527 - 11534 (2011)

Ternary organic crystals consisting of an L-tartaric acid-derived dicarboxylic acid, a commercially available achiral diamine, and a chiral secondary alcohol have been developed and characterized by X-ray crystallography. 1D, 2D, and 3D hydrogen-bonded supramolecular networks were constructed, depending on the structure of the diamine used. Benzylic and aliphatic secondary alcohols were enantioselectively incorporated into the crystal and were successfully enantioseparated with up to 86 and 79 % enantiomeric excess (ee), respectively. Selective incorporation of one enantiomer of 2-butanol, which is a small chiral aliphatic alcohol, was achieved by the cooperative effects of hydrogen bonds, CH...π interactions, and van der Waals interactions between the guest and host molecules, with the aid of two water molecules. The high host potential of the binary supramolecular system is mainly attributed to the skewed conformation of two rigid aromatic groups of tartaric acid derivatives, which prevents dense packing of the molecules and enhances the formation of multicomponent inclusion crystals.

Furanoside thioether-phosphinite ligands for Rh-catalyzed asymmetric hydrosilylation of ketones

Dieguez, Montserrat,Pamies, Oscar,Claver, Carmen

, p. 3877 - 3880 (2005)

A series of thioether-phosphinite ligands, easily prepared in a few steps from inexpensive d-(+)-xylose, were tested in the Rh-catalyzed hydrosilylation of ketones. Systematic variation of the electronic and steric properties of the thioether moiety provi

Ruthenium-catalysed asymmetric hydrogenation of ketones using QUINAPHOS as the ligand

Burk, Simon,Francio, Giancarlo,Leitner, Walter

, p. 3460 - 3462 (2005)

Highly enantioselective ruthenium-catalysed hydrogenation of aromatic ketones is achieved with (Ra,SC)-QUINAPHOS in the presence of achiral and chiral diamines as co-catalysts. The Royal Society of Chemistry 2005.

Bulky achiral triarylphosphines mimic BINAP in Ru(II)-catalyzed asymmetric hydrogenation of ketones

Jing, Qing,Zhang, Xue,Sun, Jie,Ding, Kuiling

, p. 1193 - 1197 (2005)

In the present work, we report on catalysis of the enantioselective hydrogenation of ketones with Ru(II) complexes composed of cheap achiral monodentate phosphine ligands in combination with an enantiopure 1,2-diamine, affording a variety of optically active secondary alcohols with high efficiency and enantioselectivity. The steric impact of achiral monophosphine ligands in Ru complexes was found to be a critical factor for the high enantioselectivity of the reaction. This finding throws some light on a long-standing challenge, the high cost of chiral bisphosphine ligands, associated with an industrial application of the asymmetric hydrogenation of ketones.

Accessing N-Stereogenicity through a Double Aza-Michael Reaction: Mechanistic Insights

Kohrt, Sonja,Santschi, Nico,Cvengro, Jn

, p. 390 - 403 (2016)

Further development of the chemistry and applications of chiral compounds that possess configurationally stable stereogenic nitrogen atoms is hampered by the lack of efficient strategies to access such compounds in an enantiomerically pure form. Esters of propiolic acid and chiral alcohols were evaluated as cheap and readily available Michael acceptors in a diastereoselective synthesis of N-stereogenic compounds by means of a double aza-Michael conjugate addition. Diastereomeric ratios of up to 74:26 and high yields were achieved with (-)-menthyl propiolate as a substrate. Furthermore, a detailed mechanistic investigation was undertaken to shed some light on the course of this domino transformation. Kinetic studies revealed that the protic-solvent additive acts as a Bronsted acid and activates the ester toward the initial attack of the tetrahydrodiazocine partner. Conversely, acidic conditions proved unfavorable during the final cyclization step that provides the product.

Asymmetric reduction of ketones by Geotrichum candidum: immobilization and application to reactions using supercritical carbon dioxide

Matsuda, Tomoko,Marukado, Ryo,Mukouyama, Masaharu,Harada, Tadao,Nakamura, Kaoru

, p. 2272 - 2275 (2008)

The enantioselectivity for the reduction of ketones by Geotrichum candidum NBRC 5767 was improved upon immobilization of the whole cell onto an ion exchange resin with polyallylamine. Furthermore, immobilization of the cell enhanced the stability of the enzyme and enabled a continuous-flow reaction under normal aqueous conditions. The biocatalyst was also applied to the reaction in supercritical carbon dioxide.

Asymmetric hydrogenation of ketones catalyzed by RuII-bicp complexes.

Genov, Daniel G,Ager, David J

, p. 2816 - 2819 (2004)

-

TADDOL-derived phosphites and phosphoramidites for efficient rhodium-catalyzed asymmetric hydroboration

Moteki, Shin A.,Wu, Di,Chandra, Kusum L.,Sahadeva Reddy,Takacs, James M.

, p. 3097 - 3100 (2006)

Two simple TADDOL-derived monodentate ligands, the (1R,2S)-2- phenylcyclohexanol-derived phosphite and the N,N-(phenylbenzyl)-phosphoramidite, give comparably high levels of enantioselectivity (90-96% ee) in the rhodium-catalyzed hydroborations of substituted styrenes bearing either electron-donating or electron-withdrawing substituents. Rhodium(I) chloride and tetrafluoroborate catalyst precursors give comparable results. Pinacolborane is superior to catecholborane in these reactions.

A series of novel β-hydroxyamide based catalysts for borane-mediated enantioselective reductions of prochiral ketones: Dedicated to Professor Halil Hosgoren on the occasion of his 66th birthday

Azizoglu, Murat,Erdogan, Asl?,Arslan, Nevin,Turgut, Y?lmaz,Hosgoren, Halil,Pirinccioglu, Necmettin

, p. 614 - 622 (2016)

The enantioselective reduction of prochiral ketones with borane in the presence of a chiral ligand has received considerable attention. Hydroxylamine-based chiral ligands with amide and hydroxyl functions in the presence of other co-ordinating groups are highly effective in these asymmetric reductions. The current work presents a simple one step synthesis of a series of β-hydroxyamide-based ligands from the reaction between 3-hydroxy-2-naphthoic acid and chiral amino alcohols and their applications as catalysts in asymmetric borane-mediated reductions of aromatic prochiral ketones in THF. The reductions provided the corresponding secondary alcohols with up to 96% ee and in good to excellent yields (89–99%). DFT calculations at B3LYP/6-31+g(d) level offered theoretical models to account for the enantioselectivity imposed by the chiral ligands in the reductions of the ketones.

Compartmentalized Nanoreactors for One-Pot Redox-Driven Transformations

Qu, Peiyuan,Kuepfert, Michael,Jockusch, Steffen,Weck, Marcus

, p. 2701 - 2706 (2019)

This contribution introduces poly(2-oxazoline)-based shell cross-linked micelles (SCMs) as nanoreactors to realize one-pot redox-driven deracemizations of secondary alcohols in aqueous media. TEMPO and Rh-TsDPEN moieties are spatially positioned into the hydrophilic corona and the hydrophobic micelle core, respectively. TEMPO catalyzes the oxidation of racemic secondary alcohols into ketones, while Rh-TsDPEN catalyzes the asymmetric transfer hydrogenation (ATH) of these ketones to afford enantioenriched secondary alcohols. Both catalysts, the Rh-TsDPEN complex and TEMPO, are incompatible with each other and the SCMs are designed to provide indispensable catalyst site isolation. Kinetic studies show that the SCMs enhance the reactivity of the immobilized catalysts, in comparison to those for the unsupported analogues under the same reaction conditions. Our nanoreactors can perform deracemizations on a broad range of secondary alcohol substrates and are reusable in a continuous manner while maintaining high activity.

Preparation of new, optically active 1,2-ferrocenyldiamine ligands and their application to ruthenium-catalyzed asymmetric transfer hydrogenation of ketones

Fukuzawa, Shin-Ichi,Suzuki, Takashi

, p. 1012 - 1016 (2006)

The treatment of (R,R)-1,2-bis(1-acetoxy-1-phenylmethyl)-ferrocene (1) with azidotrimethylsilane in CH2Cl2 in the presence of a catalytic amount of a Lewis acid such as Cu(OTf)2 or Sc(OTf) 3, at -40°C for 24 h,

The influence of electronic effects and temperature on the enantioselective reductions of acetophenone derivatives with (-)-diisopinocampheylchloroborane - A dynamic model of enantioselection

Wiegers, Andreas,Scharf, Hans-Dieter

, p. 2303 - 2312 (1996)

The asymmetric reduction of acetophenone derivatives with (-)-diisopinocampheylchloroborane, with respect to temperature and different electronic situations present in the carbonyl group, has been investigated. The temperature dependence of enantioselecti

Asymmetric reduction of ketones by Geotrichum candidum in the presence of Amberlite Xad, A solid organic solvent

Nakamura, Kaoru,Fujii, Mikio,Ida, Yoshiteru

, p. 3205 - 3211 (2000)

Asymmetric reduction of ketones by Geotrichum candidum in the presence of Amberlite XAD, a solid organic solvent, was described. A hydrophobic polymer, XAD, was used as material to control the stereochemical course of microbial reductions. Aliphatic and aromatic ketones were reduced to the corresponding (S)-alcohols in excellent enantiomeric excess (ee) in the presence of XRD while low enantioselectivities were observed in the absence of the polymer.

Asymmetric reduction of acetophenone derivatives by Lens culinaris

Ferreira, Daniele Alves,Da Costa Assun??o, Jo?o Carlos,De Lemos, Telma Leda Gomes,Monte, Francisco José Queiroz

, p. 469 - 475 (2012)

The enzymatic reduction of acetophenone derivatives has been evaluated using whole cells from the edible plant lentil (Lens culinaris) as biocatalyst to afford chiral (R) and (S)-alcohols in enantiomeric excess 68-99%. Acetophenone was selected as the model substrate for enantioselective bioreduction. The reaction was performed under a range of conditions in order to optimize the bioreduction procedure with respect to reaction time, media and optimal mass of lentil. With substituted (fluorine, chlorine, bromine, methyl, hydroxyl, methoxy, amino and nitro groups) acetophenones, electronic and steric influences on the course of the reaction were observed.

Ru-BICP-catalyzed asymmetric hydrogenation of aromatic ketones

Cao, Ping,Zhang, Xumu

, p. 2127 - 2129 (1999)

-

Asymmetric borane reduction of prochiral ketones catalyzed by helical poly[(S)-3-vinyl-2,2'-dihydroxy-1,1'-binaphthyl]

Qin, Guochang,Chen, Yehui,Yang, Liwen,Yang, Nianfa,Yang, Zhusheng

, p. 422 - 424 (2015)

The application of helical poly[(S)-3-vinyl-2,2'-dihydroxy-1, 1'-binaphthyl] (L) in the asymmetric borane reduction of prochiral ketones was studied. The results showed that L? had excellent catalytic activity as well as enantioselectivity, giving up to 96% yield and up to 99% enantiomeric excess (ee) of the corresponding secondary alcohol at 25 °C. Moreover, L? can be easily recovered and reused without loss of catalytic activity.

Asymmetric hydrogenation of ketones catalyzed by a ruthenium(ii)-indan- ambox complex

Li, Wei,Hou, Guohua,Wang, Chunjiang,Jiang, Yutong,Zhang, Xumu

, p. 3979 - 3981 (2010)

(S,R)-Indan-ambox ligand and its ruthenium(ii) complex have been prepared and successfully applied to asymmetric hydrogenation of prochiral simple ketones. A wide range of unfunctionalized ketones are reduced by Ru(ii)-indan-ambox catalyst with excellent enantioselectivities (up to 97% ee).

Asymmetric transfer hydrogenation of ketones catalyzed by rhodium block copolymer complexes in aqueous micelles

Elias, Shlomi,Goren, Kerem,Vigalok, Arkadi

, p. 2619 - 2622 (2012)

High activity and enantioselectivity were achieved in the rhodium-catalyzed asymmetric transfer-hydrogenation reactions of ketones in pure water using a novel amphiphilic block polypeptide ligand. The covalent linkage of the catalyst to the block copolymer plays a significant role and provides higher conversions and better recyclability than regular micellar or nonmicellar systems. Georg Thieme Verlag KG Stuttgart · New York.

Mechanistic Studies of Copper-Catalyzed Asymmetric Hydroboration of Alkenes

Xi, Yumeng,Hartwig, John F.

, p. 12758 - 12772 (2017)

Mechanistic studies of the copper-catalyzed asymmetric hydroboration of vinylarenes and internal alkenes are reported. Catalytic systems with both DTBM-SEGPHOS and SEGPHOS as the ligands have been investigated. With DTBM-SEGPHOS as the ligand, the resting state of the catalyst, which is also a catalytic intermediate, for hydroboration of 4-fluorostyrene is a phenethylcopper(I) complex ligated by the bisphosphine. This complex was fully characterized by NMR spectroscopy and X-ray crystallography. The turnover-limiting step in the catalytic cycle for the reaction of vinylarenes is the borylation of this phenethylcopper complex with pinacolborane (HBpin) to form the boronate ester product and a copper hydride. Experiments showed that the borylation occurs with retention of configuration at the benzylic position. β-Hydrogen elimination and insertion of the alkene to reform this phenethylcopper complex is reversible in the absence of HBpin but is irreversible during the catalytic process because reaction with HBpin is faster than β-hydrogen elimination of the phenethylcopper complex. Studies on the hydroboration of a representative internal alkene, trans-3-hexenyl 2,4,6-trichlorobenzoate, which undergoes enantio- and regioselective addition of HBpin catalyzed by DTBM-SEGPHOS, KOtBu, and CuCl, also was conducted, and these studies revealed that a DTBM-SEGPHOS-ligated copper(I) dihydridoborate complex is the resting state of the catalyst in this case. The turnover-limiting step in the catalytic cycle for hydroboration of the internal alkene is insertion of the alkene into a copper(I) hydride formed by reversible dissociation of HBpin from the copper dihydridoborate species. With SEGPHOS as the ligand, a dimeric copper hydride was observed as the dominant species during the hydroboration of 4-fluorostyrene, and this complex is not catalytically competent. DFT calculations provide a view into the origins of regio- and enantioselectivity of the catalytic process and indicate that the charge on the copper-bound carbon and delocalization of charge onto the aryl ring control the rate of the alkene insertion and the regioselectivity of the catalytic reactions of vinylarenes.

Ru(II) complexes of cyclohexane diamine and monodentate phosphorus ligands for asymmetric ketone hydrogenation

Xu, Yingjian (Andy),Docherty, Gordon F.,Woodward, Gary,Wills, Martin

, p. 2925 - 2929 (2006)

The incorporation of a trans-1,2-diaminocyclohexane in place of DPEN provides improvements in enantioselectivity to asymmetric ketone hydrogenation reactions using BrXuPHOS-Ru-diamine catalysts. Substrates containing halogenated aryl rings are particularly compatible with this catalyst, however, α-chlorinated ketones remain resistant to reduction under any conditions.

Relationship between the structure and enantioselectivity in the asymmetric reduction of 2′,6′-disubstituted acetophenones with DIP-Chloride. An ab initio study

Ramachandran, P. Veeraraghavan,Gong, Baoqing,Brown, Herbert C.,Francisco, Joseph S.

, p. 2603 - 2605 (2004)

Using computational and chemical studies, a relationship between the % ee achieved and the dihedral angles between the plane of the aromatic ring and the plane containing the carbonyl group has been established for asymmetric reductions with B-chlorodiisopinocampheylborane.

Cinchona-Alkaloid-Derived NNP Ligand for Iridium-Catalyzed Asymmetric Hydrogenation of Ketones

Zhang, Lin,Zhang, Ling,Chen, Qian,Li, Linlin,Jiang, Jian,Sun, Hao,Zhao, Chong,Yang, Yuanyong,Li, Chun

supporting information, p. 415 - 419 (2022/01/12)

Most ligands applied for asymmetric hydrogenation are synthesized via multistep reactions with expensive chemical reagents. Herein, a series of novel and easily accessed cinchona-alkaloid-based NNP ligands have been developed in two steps. By combining [Ir(COD)Cl]2, 39 ketones including aromatic, heteroaryl, and alkyl ketones have been hydrogenated, all affording valuable chiral alcohols with 96.0-99.9% ee. A plausible reaction mechanism was discussed by NMR, HRMS, and DFT, and an activating model involving trihydride was verified.

Method for synthesizing chiral secondary alcohol compound

-

Paragraph 0038-0043; 0064-0068, (2021/05/29)

The invention discloses a method for synthesizing a chiral secondary alcohol compound. The method comprises the following step of: reacting a ketone compound in an aprotic organic solvent at room temperature and inert gas atmosphere under the action of a chiral cobalt catalyst and an activating agent by taking a combination of bis(pinacolato)diboron and alcohol or water as a reducing agent to obtain the chiral secondary alcohol compound. According to the method disclosed by the invention, a combination of pinacol diborate and alcohol or water which are cheap, stable and easy to obtain is taken as a reducing agent, and a ketone compound is efficiently reduced to synthesize a corresponding chiral secondary alcohol compound in an aprotic organic solvent under the action of a chiral cobalt catalyst; in a chiral cobalt catalyst adopted by the method, when a chiral ligand is PAOR, an activating agent is NaBHEt3 or NaOtBu and an adopted raw material is aromatic ketone, the yield is 80% or above, and the optical purity is 90% or above; and when the adopted raw material is alkane ketone, the yield can reach 70% or above, and the optical purity can reach 80% or above.

Dynamic Kinetic Resolution of Alcohols by Enantioselective Silylation Enabled by Two Orthogonal Transition-Metal Catalysts

Oestreich, Martin,Seliger, Jan

, p. 247 - 251 (2020/10/29)

A nonenzymatic dynamic kinetic resolution of acyclic and cyclic benzylic alcohols is reported. The approach merges rapid transition-metal-catalyzed alcohol racemization and enantioselective Cu-H-catalyzed dehydrogenative Si-O coupling of alcohols and hydrosilanes. The catalytic processes are orthogonal, and the racemization catalyst does not promote any background reactions such as the racemization of the silyl ether and its unselective formation. Often-used ruthenium half-sandwich complexes are not suitable but a bifunctional ruthenium pincer complex perfectly fulfills this purpose. By this, enantioselective silylation of racemic alcohol mixtures is achieved in high yields and with good levels of enantioselection.

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