101220-38-6Relevant articles and documents
One-pot highly diastereoselective annulation to N-unprotected tetrasubstituted 2-pyrrolines
Meninno, Sara,Capobianco, Amedeo,Peluso, Andrea,Lattanzi, Alessandra
supporting information, p. 2137 - 2140 (2015/04/27)
A one-pot DABCO-catalysed Michael addition of glycine imine-derived esters to trans-2-aroyl-3-arylacrylonitriles followed by a deprotection/cyclization/tautomerization sequence afforded tetrasubstituted N-unprotected trans-2-pyrrolines in up to 96% yield.
Microwave synthesis of α-cyano chalcones
Deshpande, Shyam J.,Leger, Paul R.,Sieck, Stephen R.
supporting information; experimental part, p. 1772 - 1775 (2012/05/04)
A novel methodology for facile production of α-cyano chalcones under microwave irradiation is described. Utilizing a Knoevenagel condensation between benzoylacetonitriles and aromatic aldehydes, substituted chalcones are generated via a 15-min, one-pot synthesis. Diversification of aromatic groups, including electron-withdrawing, electron-donating, and heterocyclic substitutions, has led to the isolation of over twenty colored, solid chalcone products. Furthermore the methodology can be extended to the synthesis of benzylidenemalononitriles as well as methyl and ethyl α-cyano cinnamates.