1012309-76-0Relevant articles and documents
Desymmetization of a meso-allylic acetal by enantioselective conjugate elimination
Xu, Ling,Regnier, Thomas,Lemigre, Loc,Cardinael, Pascal,Combret, Jean-Claude,Bouillon, Jean-Philippe,Blanchet, Jerome,Rouden, Jacques,Harrison-Marchand, Anne,Maddaluno, Jacques
, p. 729 - 732 (2008)
An unprecedented enantioselective deprotonation/conjugate elimination sequence, which transforms an allylic meso-dioxepane into a chiral diene, is described. The best desymmetrization conditions (ee up to 70%) involve s-BuLi and sparteine at -78 °C in THF.