1012315-29-5Relevant articles and documents
Ring-closing alkyne metathesis in the synthesis of alkyne-linked glycoamino acids
Groothuys, Stan,Van Den Broek,Kuijpers, Brian H. M.,Ijsselstijn, Maarten,Van Delft, Floris L.,Rutjes, Floris P. J. T.
, p. 111 - 115 (2008/09/21)
Synthesis of alkyne-linked glycoamino acids via ring-closing alkyne metathesis is investigated. Two different strategies are described to attach alkynylamino acids to an alkynyl sugar, either via a linker at O-4 or at O-9 of the alkynyl sugar. Ring-closing alkyne metathesis of the O-4 linked diynes failed to proceed, but alkyne-linked glycoamino acids of different chain length were effectively synthesized via attachment at O-9. Georg Thieme Verlag Stuttgart.
