101234-68-8Relevant articles and documents
Synthesis and biological activity of 3-(N-substituted pyridinium-4-thiomethyl)-7α-formamido cephalosporins
Guest,Adams,Basker,Brain,Branch,Harrington,Neale,Pearson,Zomaya
, p. 1279 - 1288 (2007/10/02)
The synthesis and antibacterial activity of a series of 3-(1-substituted pyridinium-4-thiomethyl)-7α-formamido cephalosporins is described. All the derivatives showed good potency and stability to bacterial β-lactamases. The antibacterial efficacy seen with the N-alkyl pyridinium substituents was enhanced by the introduction of a catecholic side chain at C-7 and by preparation of N-(substituted amino)pyridinium derivatives.
Cephalosporin derivatives
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, (2008/06/13)
This is a class of antibacterial compounds of the formula: STR1 wherein Y is straight or branched alkyl or alkenyl chain, cycloalkanomethyl of 3-6 carbon atoms, each group being optionally substituted by halogen, or a group STR2 wherein n is 0 or an integer of 1-3, A is a group --COR3 wherein R3 is hydroxy, a group STR3 wherein R4 and R5, which may be the same or different, are hydrogen or alkyl of 1-5 carbon atoms, a group STR4 or a 5- or 6-membered heterocyclic group containing nitrogen and/or sulfur, and R1 and R2, which may be the same or different, are hydrogen, alkyl of 1-5 carbon atoms, or R1 and R2 may be combined together to form cycloalkylidene of 3-5 carbon atoms, and Z is a group of the formula: STR5 wherein m is 0 or an integer of 3-5, R6 is hydrogen or alkyl of 1-3 carbon atoms, and R7, when m is an integer of 3-5, is alkyl of 1-5 carbon atoms, alkenyl, cyclopropyl, a group --(CH2)p B wherein p is 0 or an integer of 1-3 and B is amino, alkyl-substituted amino, hydroxy, carboxy, carbamoyl, trifluoromethyl, sulfonic acid, sulfonic acid amide, alkylthio or cyano or, when m is 0, is alkyl of 1-5 carbon atoms, which may optionally be substituted by halogen, alkenyl, a group STR6 wherein R8 is hydrogen, alkyl of 1-4 carbon atoms or phenyl, or cyclopropyl, and a salt thereof.