1012369-67-3Relevant articles and documents
N-heterocyclic carbene and Bronsted acid cooperative catalysis: Asymmetric synthesis of trans -γ-Lactams
Zhao, Xiaodan,Dirocco, Daniel A.,Rovis, Tomislav
, p. 12466 - 12469 (2011/09/16)
An efficient enantioselective approach to form trans-γ-lactams in up to 99% yield, 93% ee, and >20/1 dr using unactivated imines has been developed. The cyclohexyl-substituted azolium and the weak base sodium o-chlorobenzoate are most suitable for this tr