101241-21-8Relevant academic research and scientific papers
A molecular chalice with hydrophobic walls and a hydrophilic rim: Self-assembly and complexation properties
Vidal, Marc,Kairouz, Vanessa,Dewolf, Christine,Schmitzer, Andreea R.
supporting information; experimental part, p. 12834 - 12836 (2012/01/14)
We describe the synthesis of a diphenylglycoluril/dibenzo-crown-6 molecular chalice, the self-assembly at the air/water interface and its complexation properties in solution and at the water/chloroform interface.
Synthesis and crystal structure of a novel molecular clip from diphenylglycoluril and phthalhydrazide
Sheng-Li, Hu,Zhi-Guo, Wang,Wen-Bing, Sun
scheme or table, p. 145 - 146 (2010/07/05)
A novel molecular clip from diphenylglycoluril and phthalhydrazide has been synthesised. Its structure and conformation was confirmed by single crystal X-ray diffraction.
A rapid and efficient microwave-assisted synthesis of hydantoins and thiohydantoins
Muccioli, Giulio G.,Poupaert, Jacques H.,Wouters, Johan,Norberg, Bernadette,Poppitz, Wolfgang,Scriba, Gerhard K.E.,Lambert, Didier M.
, p. 1301 - 1307 (2007/10/03)
The present paper describes studies on the synthesis of the antiepileptic drug phenytoin, and of structurally related derivatives. First, the influence of the solvent has been investigated in the microwave-assisted synthesis of the drug, resulting in a yield improvement and a cleaner reaction. Second, a two-step reaction is described to synthesize selectively and in high yields phenytoin. The first step consists in microwave activation of the reaction of benzil with thiourea, the second step includes the conversion of the resulting 2-thiohydantoin to phenytoin using hydrogen peroxide. Moreover, microwave activation is a very convenient method for the synthesis of 3-alkylated phenytoin derivatives, resulting in a much more selective method than the previously reported procedure using alkylating agents.
