101241-56-9

Basic information

• Product Name: 2-amino-5-nitrodiphenylsulfone
• Synonyms: 2-amino-5-nitrodiphenylsulfone
• CAS NO: 101241-56-9
• Molecular Formula: C12H10N2O4S
• Molecular Weight: 278.2838
• Mol File: 101241-56-9.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-amino-5-nitrodiphenylsulfone(CAS DataBase Reference)
• NIST Chemistry Reference: 2-amino-5-nitrodiphenylsulfone(101241-56-9)
• EPA Substance Registry System: 2-amino-5-nitrodiphenylsulfone(101241-56-9)

Safety Data

• Hazardous Substances Data: 101241-56-9(Hazardous Substances Data)

Usage

General Description

2-amino-5-nitrodiphenylsulfone, also known as dapsone, is a synthetic organic compound that belongs to the class of sulfones. It is a yellow crystalline solid that is used primarily as an antibacterial and anti-inflammatory agent. Dapsone is commonly used in the treatment of leprosy, dermatitis herpetiformis, and malaria. It works by inhibiting the synthesis of dihydrofolic acid, which is essential for the growth and reproduction of certain bacteria and parasites. Dapsone also has anti-inflammatory properties, making it effective in the treatment of skin conditions such as acne and inflammatory dermatoses. However, dapsone can cause side effects such as anemia and allergic reactions, and it should be used with caution under the supervision of a healthcare professional.

Relevant articles and documents

Nitrodiaryl sulfoxide derivatives, process for their preparation and pharmaceutical and pesticidal compositions containing them as active ingredient

The invention relates to a new process for the preparation of aminodiaryl sulfoxide derivatives of the formula (I), STR1 wherein X is halogen, alkoxy having from 1 to 6 carbon atoms or a group --(N,R,R1), in which R and R1 are hydrogen or alkyl having from 1 to 6 carbon atoms, R2 is hydrogen, halogen, alkyl having from 1 to 6 carbon atoms, alkoxy having from 1 to 6 carbon atoms or phenyl or phenylthio both optionally substituted by one or more identical or different halogen(s) and/or amino group(s), and acid addition salts thereof. The compounds of formula (I) are pharmaceutically active, in particular are potent anthelmintics, or can be used as active ingredients in pesticidal compositions. The invention therefore relates to pharmaceutical and pesticidal compositions containing compounds of formula (I) or salts thereof as active ingredient. Compounds of formula (I), in which the substituents are as defined above, but if X stands for a group --N(R,R1) in which R and R1 both represent hydrogen, and X is in para-position related to the sulfoxide group, then R2 is other than hydrogen, halogen, alkyl having from 1 to 6 carbon atoms and alkoxy having from 1 to 6 carbon atoms, and the acid addition salts thereof, are new. These new compounds are also subject of the present invention.