10125-86-7

Basic information

• Product Name: N,N-Bis(2-chloroethyl)-1,1-dimethylethan-1-amine
• Synonyms: N,N-Bis(2-chloroethyl)-1,1-dimethylethan-1-amine
• CAS NO: 10125-86-7
• Molecular Formula: C₈H₁₇Cl₂N
• Molecular Weight: 198.1333
• Mol File: 10125-86-7.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 324.35°C (rough estimate)
• Flash Point: 58°C
• Appearance: /
• Density: 1.1707 (rough estimate)
• Vapor Pressure: 1.34mmHg at 25°C
• Refractive Index: 1.6100 (estimate)
• PKA: 6?+-.0.50(Predicted)
• CAS DataBase Reference: N,N-Bis(2-chloroethyl)-1,1-dimethylethan-1-amine(CAS DataBase Reference)
• NIST Chemistry Reference: N,N-Bis(2-chloroethyl)-1,1-dimethylethan-1-amine(10125-86-7)
• EPA Substance Registry System: N,N-Bis(2-chloroethyl)-1,1-dimethylethan-1-amine(10125-86-7)

Safety Data

• Hazardous Substances Data: 10125-86-7(Hazardous Substances Data)

Usage

InChI:InChI=1/C8H17Cl2N/c1-8(2,3)11(6-4-9)7-5-10/h4-7H2,1-3H3

Upstream product

• 2160-93-2 N-tert-butyldiethanolamine 

Downstream Products

• 16192-78-2 Phenyl-methanethiosulfonic acid S-{2-[tert-butyl-(2-phenylmethanesulfonylsulfanyl-ethyl)-amino]-ethyl} ester 
• 16186-51-9 C₂₂H₃₁NO₄S₄ 
• 16192-81-7 C₂₀H₂₇NO₄S₄ 
• 17675-53-5 C₂₀H₂₅Br₂NO₄S₄ 
• 1071485-56-7 (1-tert-butyl-4-phenylpiperidin-4-yl)methanamine 
• 40489-73-4 1-benzyl-4-(tert-butyl)piperazine 
• 212770-80-4 1-tert-butyl-4-(4-methoxy-benzenesulfonyl)-piperidine-4-carboxylic acid ethyl ester 
• 639497-01-1 1-tert-butyl-4-[4'-(4,4,4-trifluorobutyl)biphenyl-4-sulfonyl]piperidine-4-carboxylic acid tert-butyl ester 
• 374716-77-5 N-tert-butylbisbis[2-(o-aminophenoxy)ethyl]amine 
• 694514-84-6 N,N-bis{2-[di-(4-tolyl)phosphino]ethyl}-N-tert-butylamine 
• 87289-72-3 4-cyano-4-phenyl-N-tert-butylpiperidine 

Relevant articles and documents

N-HYDROXY-2-(ALKYL, ARYL, OR HETEROARYL SULFANYL, SULFINYL OR SULFONYL)-3-SUBSTITUTED ALKYL, ARYL OR HETEROARYLAMIDES AS MATRIX METALLOPROTEINASE INHIBITORS

Matrix metalloproteinases (MMPs) are a group of enzymes that have been implicated in the pathological destruction of connective tissue and basement membranes. These zinc containing endopeptidases consist of several subsets of enzymes including collagenases, stromelysins and gelatinases. TNF- alpha converting enzymes (TACE), a pro-inflammatory cytokine, catalyze the formation of TNF- alpha from membrane-bound TNF- alpha precursor protein. It is expected that small molecule inhibitors of MMPs and TACE therefore have the potential for treating a variety of disease states. The present invention provides low molecular weight, non-peptide inhibitors of matrix metalloproteinases (MMPs) and TNF- alpha converting enzyme (TACE) for the treatment of arthritis, tumor metastasis, tissue ulceration, abnormal wound healing, periodontal disease, bone disease, diabetes (insulin resistance) and HIV infection. The compounds of this invention are represented by formula (I), where R, R, R and R are described herein.