101250-48-0

Basic information

• Product Name: 5-benzylmorpholin-3-one
• Synonyms: 5-benzylmorpholin-3-one;(S)-5-benzylMorpholin-3-one;(5S)-5-(phenylMethyl)-3-Morpholinone;(5S)-5-BenzylMorpholin-3-one;(S)-5-(Phenylmethyl)-3-morpholinone;(S)-5-(Phenylmethyl)-3-morpholinone,99%e.e.;3-Morpholinone, 5-(phenylmethyl)-, (5S)
• CAS NO: 101250-48-0
• Molecular Formula: C₁₁H₁₃NO₂
• Molecular Weight: 191
• Mol File: 101250-48-0.mol
• Article Data: 14

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 5-benzylmorpholin-3-one(CAS DataBase Reference)
• NIST Chemistry Reference: 5-benzylmorpholin-3-one(101250-48-0)
• EPA Substance Registry System: 5-benzylmorpholin-3-one(101250-48-0)

Safety Data

• Hazardous Substances Data: 101250-48-0(Hazardous Substances Data)

Usage

General Description

5-benzylmorpholin-3-one, also known as benzylmorpholone, is a chemical compound that belongs to the class of morpholine derivatives. It is a heterocyclic compound containing a morpholine ring with a benzyl group attached to the nitrogen atom. 5-benzylmorpholin-3-one has industrial applications and is used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. It also exhibits potential biological activities and is being studied for its medicinal properties. Additionally, 5-benzylmorpholin-3-one has been identified as a key compound in the synthesis of various organic compounds, making it of interest to the chemical and pharmaceutical industries.

Upstream product

• 3182-95-4 L-Phenylalaninol 
• 79-04-9 chloroacetyl chloride 
• 207120-52-3 (S)-2-chloro-N-(1-hydroxy-3-phenylpropan-2-yl)acetamide 
• 105-39-5 chloroacetic acid ethyl ester 
• 94193-78-9 (S)-2-chloro-N-(1-hydroxy-3-phenylpropan-2-yl)acetamide 
• 2382-86-7 methyl (S)-2-(2-chloroacetamido)-3-phenylpropanoate 
• 7524-50-7 methyl (2S)-2-amino-3-phenylpropanoate hydrochloride 
• 63-91-2 L-phenylalanine 
• 221045-94-9 (S)-(-)-2-amino-3-phenyl-1-(tert-butyldimethylsilyloxy)propane 

Downstream Products

• 1162182-68-4 C₁₃H₁₇NO₂ 
• 1607483-19-1 C₁₆H₂₃NO₄ 
• 1607483-20-4 C₁₇H₂₅NO₄ 
• 1607483-23-7 C₁₃H₂₀NO₄P 
• 1621604-13-4 (3R,5S)-5-benzylmorpholine-3-phosphonic acid 
• 1311281-95-4 (S,E)-3-benzyl-5-(2-mesitylhydrazono)morpholine hydrochloride 
• 1276429-72-1 (S)-5-benzyl-2-mesityl-6,8-dihydro-5H-[1,2,4]triazolo[3,4-c][1,4]oxazin-2-ium chloride 
• 219993-45-0 Methanesulfonic acid 2-[(S)-5-benzyl-4-(4-methoxy-benzyl)-3-oxo-morpholin-2-yl]-ethyl ester 
• 194599-88-7 (S)-5-Benzyl-2-(5-iodo-pentyl)-4-(4-methoxy-benzyl)-morpholin-3-one 
• 194597-84-7 (S)-5-Benzyl-2-(5-chloro-pentyl)-4-(4-methoxy-benzyl)-morpholin-3-one 

Relevant articles and documents

A synthesis of (S)-3-(phenylmethyl)morpholine from (S)-phenylalanol

A preparation of (S)-3-(phenylmethyl)morpholine from (S)-phenylated is described.

Diastereoselective synthesis of novel 5-substituted morpholine-3-phosphonic acids: Further exploitation of N-acyliminium intermediates

The first diastereoselective total synthesis of 5-substituted morpholine-3-phosphonic acids is reported. The principal feature of the synthesis is the introduction of a dimethyl phosphonate group into 5-substituted morpholin-3-ones. The procedure is based

Organic base effects in NHC promoted O- to C-carboxyl transfer; Chemoselectivity profiles, mechanistic studies and domino catalysis

The O- to C-carboxyl transfer of oxazolyl carbonates promoted by triazolinylidenes, generated in situ with NEt3, shows a markedly different rate and chemoselectivity profile to the same reaction promoted by triazolinylidenes generated using KHM