101250-90-2

Basic information

• Product Name: L-Lysinol(Z)
• Synonyms: L-Lysinol(Z);H-Lysinol(Z)·HCl;L-Lys-ol;Nε-Z-L-lysinol≥ 95% (HPLC);Ne-Z-L-lysinol;Carbamic acid, N-[(5S)-5-amino-6-hydroxyhexyl]-, phenylmethyl ester
• CAS NO: 101250-90-2
• Molecular Formula: C₁₄H₂₂N₂O₃
• Molecular Weight: 132.20404
• Mol File: 101250-90-2.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: L-Lysinol(Z)(CAS DataBase Reference)
• NIST Chemistry Reference: L-Lysinol(Z)(101250-90-2)
• EPA Substance Registry System: L-Lysinol(Z)(101250-90-2)

Safety Data

• Hazardous Substances Data: 101250-90-2(Hazardous Substances Data)

Usage

Chemical Properties

Off-white solid

Upstream product

• 27894-50-4 methyl (2S)-2-amino-6-{[(benzyloxy)carbonyl]amino}hexanoate hydrochloride 
• 2389-45-9 Boc-Lys(Z)-OH 
• 1155-64-2 N₆-[(benzyloxy)carbonyl]-L-lysine 
• 82689-20-1 N⁶-benzyloxycarbonyl-N²-tert-butoxycarbonyl-L-lysinol 

Downstream Products

• 236115-88-1 ((S)-5-{2-[(1R,2R,3S,5R,6S)-3,5-Diazido-2-((2R,3R,4R,5R,6R)-3-azido-6-azidomethyl-4,5-bis-benzyloxy-tetrahydro-pyran-2-yloxy)-6-benzyloxy-cyclohexyloxy]-ethylamino}-6-hydroxy-hexyl)-carbamic acid benzyl ester 
• 101250-36-6 *,R^*)>-phenylmethyl 2-<<<1-(hydroxymethyl)-5-<<(phenylmethoxy)carbonyl>amino>pentyl>amino>carbonyl>-1-pyrrolidinecarboxylate 

Relevant articles and documents

Modular synthesis of cyclic peptidomimetics inspired by γ-turns

(Chemical Equation Presented) A series of peptidomimetics based on a γ-turn motif were synthesized using a modular approach, in which N-protected piperidones were reacted with a selection of 2-hydroxyalkyl azides derived from common L-amino acids. Hydrolysis of the initially formed iminium ethers afforded the targeted series of substituted 1,4-diazepin-5-ones.

Isoquinoline derivatives and drugs

PCT No. PCT/JP97/00240 Sec. 371 Date Jul. 29, 1998 Sec. 102(e) Date Jul. 29, 1998 PCT Filed Jan. 31, 1997 PCT Pub. No. WO97/28130 PCT Pub. Date Aug. 7, 1997The invention relates to a compound of the following general formula [I] or a medicinally acceptable salt thereof, or a solvate thereof, wherein R1 represents alkyl, alkenyl, alkynyl, alkoxy, hydroxy, cyano, or halogen; R2 represents hydrogen, hydroxy, or halogen; R3 represents hydrogen, alkyl, or amidino; Ring A represents a 5 to 11-membered cyclic amino group which may be substituted, which cyclic amino group may be bridged between two carbon atoms in optional positions. The compound of this invention is useful for the prevention or treatment of cerebral tissue impairment due to the vasospasm following cerebral hemorrhage.

Modified Di- and Tripeptides of the C-Terminal Portion of Oxytocin and Vasopressin as Possible Cognition Activation Agents

A number of peptides and modified peptides were synthesized and studied for their ability to reverse electroconvulsive shock-induced amnesia in rodents.A few of these peptides were selected for secondary evaluation in tests of short-term memory in rats and aged rhesus monkeys.A number of the peptides and modified peptides were active in the amnesia reversal test.In selected secondary tests, however, the chosen compounds failed to show significant activity in enhancing memory.New methods for preparing methyleneamino and methyleneoxy isosters of peptides are reportrd.Other modified peptides also included methylenethio, methylenesulfonyl, and ethylene isosteres in place of the normal peptide amide bond.