101267-09-8

Basic information

• Product Name: 5’-pentyl-2’-hydroxyacetophenone
• Synonyms: 5’-pentyl-2’-hydroxyacetophenone
• CAS NO: 101267-09-8
• Molecular Weight: 206.285
• Mol File: 101267-09-8.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 5’-pentyl-2’-hydroxyacetophenone(CAS DataBase Reference)
• NIST Chemistry Reference: 5’-pentyl-2’-hydroxyacetophenone(101267-09-8)
• EPA Substance Registry System: 5’-pentyl-2’-hydroxyacetophenone(101267-09-8)

Safety Data

• Hazardous Substances Data: 101267-09-8(Hazardous Substances Data)

Upstream product

• 14938-35-3 4-n-pentylphenol 
• 30989-73-2 2-diethoxymethyl-1,1-diethoxyheptane 
• 63446-76-4 1-methyl-1,3-bis(trimethylsilyloxy)buta-1,3-diene 

Relevant articles and documents

Synthesis and SAR Study of Anticancer Protoflavone Derivatives: Investigation of Cytotoxicity and Interaction with ABCB1 and ABCG2 Multidrug Efflux Transporters

There is a constant need for new therapies against multidrug-resistant (MDR) cancer. Natural compounds are a promising source of novel anticancer agents. We recently showed that protoflavones display activity in MDR cancer cell lines that overexpress the P-glycoprotein (P-gp) drug efflux pump. In this study, 52 protoflavones, including 22 new derivatives, were synthesized and tested against a panel of drug-sensitive parental cells and their MDR derivatives obtained by transfection with the human ABCB1 or ABCG2 genes, or by adaptation to chemotherapeutics. With the exception of protoapigenone, identified as a weak ABCG2 substrate, all protoflavones bypass resistance conferred by these two transporters. The majority of the compounds were found to exhibit mild to strong (up to 13-fold) selectivity against the MCF-7Dox and KB-V1 cell lines, but not to transfected MDR cells engineered to overexpress the MDR transporters. Our results suggest that protoflavones can overcome MDR cancer by evading P-gp-mediated efflux.