10128-06-0

Basic information

• Product Name: (2S)-2-Amino-3-(3,4-dimethoxyphenyl)-2-methyl-propanoic acid
• Synonyms: DL-2-AMINO-3-(3,4-DIMETHOXY-PHENYL)-2-METHYL-PROPIONIC ACID;DL-3-(3,4-DIMETHOXYPHENYL)-2-METHYLALANINE;(2S)-2-Amino-3-(3,4-dimethoxyphenyl)-2-methyl-propanoic acid;4-DiMethoxyphenyl)-2-Methylalanine
• CAS NO: 10128-06-0
• Molecular Formula: C₁₂H₁₇NO₄
• Molecular Weight: 239.27
• EINECS: 679-927-3
• Product Categories: Pharmaceutical Intermediates
• Mol File: 10128-06-0.mol
• Article Data: 1

Chemical Properties

• Melting Point: 274-275 °C (decomp)
• Boiling Point: 379.6 °C at 760 mmHg
• Flash Point: 183.4 °C
• Appearance: /
• Density: 1.186 g/cm³
• PKA: 2.27±0.26(Predicted)
• CAS DataBase Reference: (2S)-2-Amino-3-(3,4-dimethoxyphenyl)-2-methyl-propanoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (2S)-2-Amino-3-(3,4-dimethoxyphenyl)-2-methyl-propanoic acid(10128-06-0)
• EPA Substance Registry System: (2S)-2-Amino-3-(3,4-dimethoxyphenyl)-2-methyl-propanoic acid(10128-06-0)

Safety Data

• Hazardous Substances Data: 10128-06-0(Hazardous Substances Data)

Usage

Synthesis Reference(s)

The Journal of Organic Chemistry, 44, p. 2042, 1979 DOI: 10.1021/jo01326a039

Upstream product

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Relevant articles and documents

SOLID-LIQUID PHASE TRANSFER CATALYTIC SYNTHESIS OF α-AMINO ACID VIA ALKYLATION AND NUCLEOPHILIC ADDITION OF BENZALDEHYDE IMINES

A short, mild and efficient synthetic route of α-amino acid via alkylation, Michael addition and carbonyl addition as well as cycloaddition of aldimines derived from glycine and alanine esters with benzaldehyde under solid-liquid phase transfer catalytic condition has been studied.The key to solid-liquid phase transfer catalyzed reactions is the selection of a base for the various reactants.The yield is dependent on the base used.The results obtained using KOH, K2CO3 and Na2CO3 are discussed.The kinetics of solid-liquid PTC benzylation has been investigated and we propose a possible mechanism of solid-liquid PTC as an interface auto-catalytic procedure.The details of some syntheses of α-amino acids are presented.