101288-83-9Relevant academic research and scientific papers
2-Aminoadipic Acid-C(O)-Glutamate Based Prostate-Specific Membrane Antigen Ligands for Potential Use as Theranostics
Nakajima, Ryo,Nováková, Zora,Tueckmantel, Werner,Motlová, Lucia,Ba?inka, Cyril,Kozikowski, Alan P.
, p. 1099 - 1104 (2018)
The design and synthesis of prostate specific membrane antigen (PSMA) ligands derived from 2-aminoadipic acid, a building block that has not previously been used to construct PSMA ligands, are reported. The effects of both the linker length and of an N-substituent of our PSMA ligands were probed, and X-ray structures of five of these ligands bound to PSMA were obtained. Among the ligands disclosed herein, 13b showed the highest inhibitory activity for PSMA. As ligand 13b can readily be radiolabeled since its fluorine atom is adjacent to the nitrogen atom of its pyridine ring, the use of this and related compounds as theranostics can be pursued.
Stereoselective synthesis of new conformationally restricted analogues of a potent CGRP receptor antagonist
Zuev, Dmitry,Michne, Jodi A.,Huang, Hong,Beno, Brett R.,Wu, Dedong,Gao, Qi,Torrente, John R.,Xu, Cen,Conway, Charles M.,Macor, John E.,Dubowchik, Gene M.
, p. 2465 - 2468 (2007/10/03)
(Chemical Equation Presented) A stereocontrolled racemic synthesis of conformationally restricted analogues 2a and 2b of a potent CGRP receptor antagonist 1 by novel functionalization of 2-substituted octahydropyrido[1,2-a] pyrazin-6-ones is described. Th
