1012881-39-8

Basic information

• Product Name: 2-TERT-BUTYL-1,3-THIAZOLE-4-CARBOXYLIC ACID
• Synonyms: 2-TERT-BUTYL-1,3-THIAZOLE-4-CARBOXYLIC ACID;2-tert-butylthiazole-5-carboxylic acid;2-tert-Butyl-1,3-thiazole-5-carboxylic acid
• CAS NO: 1012881-39-8
• Molecular Formula: C₈H₁₁NO₂S
• Molecular Weight: 185.24344
• Product Categories: Thiazole series;Carboxylic Acids;Thiazoles, Isothiazoles &Benzothiazoles;Carboxylic Acids;Thiazoles, Isothiazoles & Benzothiazoles
• Mol File: 1012881-39-8.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 307.7±15.0 °C(Predicted)
• Appearance: /
• Density: 1.223±0.06 g/cm3(Predicted)
• PKA: 1.68±0.10(Predicted)
• CAS DataBase Reference: 2-TERT-BUTYL-1,3-THIAZOLE-4-CARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 2-TERT-BUTYL-1,3-THIAZOLE-4-CARBOXYLIC ACID(1012881-39-8)
• EPA Substance Registry System: 2-TERT-BUTYL-1,3-THIAZOLE-4-CARBOXYLIC ACID(1012881-39-8)

Safety Data

• Hazardous Substances Data: 1012881-39-8(Hazardous Substances Data)

Upstream product

• 1211695-52-1 2-tert-butyl-1,3-thiazol-5-carbaldehyde 
• 630-22-8 2,2-dimethylpropanethioamide 

Relevant articles and documents

METHODS AND COMPOUNDS FOR RESTORING MUTANT p53 FUNCTION

Mutations in oncogenes and tumor suppressors contribute to the development and progression of cancer. The present disclosure describes compounds and methods to recover wild-type function to p53 mutants. The compounds of the present disclosure can bind to mutant p53 and restore the ability of the p53 mutant to bind DNA and activate downstream effectors involved in tumor suppression. The disclosed compounds can be used to reduce the progression of cancers that contain a p53 mutation.

SUBSTITUTED BENZIMDAZOLE DERIVATIVES USEFUL AS TRPM8 RECEPTOR MODULATORS

The present invention is directed to benzimidazole derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions modulated by TRP M8, including for example, inflammatory pain, inflammatory hyperalgesia