101291-06-9

Upstream product

• 3672-49-9 phenyl(5-phenyl-1,2-oxazol-3-yl)methanone 
• 412028-64-9 2-anilino-2-oxoethanehydroxymoyl chloride 
• 536-74-3 phenylacetylene 
• 51677-09-9 methyl 5-phenylisoxazole-3-carboxylate 
• 20577-73-5 methyl 4-phenyl-2,4-dioxobutanoate 
• 14441-90-8 5-phenyl-3-isoxazolecarboxylic acid 
• 62-53-3 aniline 
• 107402-60-8 N-Phenyl-α-methoxycarbonyl-α-nitroacetamide 
• 220898-58-8 N⁽¹⁾-phenyl-2-amino-2-hydroxyiminoacetamide 

Downstream Products

• 14441-90-8 5-phenyl-3-isoxazolecarboxylic acid 

Relevant academic research and scientific papers

Synthesis of novel 5-substituted isoxazole-3-carboxamide derivatives and cytotoxicity studies on lung cancer cell line

A series of novel 5-substituted isoxazole-3-carboxamide derivatives 6 have been prepared by coupling of 5-substituted isoxazole-3-carboxylic acids 3 with substituted-3-benzyloxyaniline 5 using DCC/HOBT as coupling agent. The products 6 have been evaluated for cytotoxicity on A549 lung cancer cell line and compounds 6a, 6b, 6e, 6j are found to show moderate proliferative activity and low cytotoxicity.

Synthesis of carbamoylformhydroxymoyl chlorides and study of their reactivities

Carbamoylformhydroxymoyl chlorides were synthesized by the reactions of carbamoylformamide oximes with sodium nitrite in the presence of hydrochloric acid, and their reactivities were examined.

Synthesis of Isoxazoline-3-carboxanilides and Isoxazole-3-carboxanilides by Thermolysis of α-Methoxycarbonyl-α-nitroacetanilides in the Presence of Dipolarophiles

Isoxazoline-3-carboxanilides (5) and isoxazole-3-carboxanilides (6) were prepared in 20-63percent yields by thermolysis of α-methoxycarbonyl-α-nitroacetanilides (3) in the presence of dipolarophiles.